Pancreas oganogenesis comprises a coordinated and highly complex interplay of signaling
events and transcriptional networks that guide a step‐wise process of organ development …

The pancreas is an endoderm-derived glandular organ that participates in the regulation of
systemic glucose metabolism and food digestion through the function of its endocrine and …

Islet transplantation has poor long-term efficacy because of the lack of extracellular matrix
support and neovascularization; this limits its wide application in diabetes research. In this …

During development, pancreatic endocrine cells are specified within the pancreatic
epithelium. They subsequently delaminate out of the epithelium and cluster in the …

Rho guanosine triphosphatases (GTPases) are key regulators in a number of cellular
functions, including actin cytoskeleton remodeling and vesicle traffic. Traditionally, Rho …

The ability to form and maintain a functional system of contiguous hollow tubes is a critical
feature of vascular endothelial cells (ECs). Lumen formation, or tubulogenesis, occurs in …

The islets of Langerhans are highly organized structures that have species-specific, three-
dimensional tissue architecture. Islet architecture is critical for proper hormone secretion in …

In the develo** embryo, appropriate patterning of the endoderm fated to become
pancreas requires the spatial and temporal coordination of soluble factors secreted by the …

Islet organoids open up new strategies for diabetes treatment and pancreatic tissue
engineering. Digital light processing (DLP) bioprinting has been extensively applied to the …

Glucose-stimulated insulin secretion from the islet β-cell involves a sequence of metabolic
events and an interplay between a wide range of signaling pathways leading to the …