Progress in the design of G-quadruplex (G4) binding ligands relies on the availability of
approaches that assess the binding mode and nature of the interactions between G4 …

G-quadruplexes (G4s) are non-canonical nucleic acid secondary structures that have
gathered significant interest in medicinal chemistry over the past two decades due to their …

DNA G-quadruplexes are essential motifs in molecular biology performing a wide range of
functions enabled by their unique and diverse structures. In this study, we focus on the …

The role of alternate DNA conformations such as Z-DNA in the regulation of transcription is
currently underappreciated. These structures are encoded by sequences called flipons …

The formation of G-quadruplex structures (G4s) in vitro from guanine (G)-rich nucleic acid
sequences of DNA and RNA stabilized with monovalent cations, typically K+ and Na+, under …

Guanidine DNA quadruplex (G4-DNA) structures convey a distinctive layer of epigenetic
information that is critical for regulating key biological activities and processes as …

The role of G-quadruplexes in human cancers is increasingly well-defined. Accordingly, G-
quadruplexes can be suitable drug targets and many small molecules have been identified …

Several G-quadruplex nucleic acid (G4s) ligands have been developed seeking target
selectivity in the past decade. Naphthalene diimide (NDI)-based compounds are particularly …

The dynamic interplay between guanine-quadruplex (G4) structures and pathogenicity
islands (PAIs) represents a captivating area of research with implications for understanding …

The evolution of genomes in all life forms involves two distinct, dynamic types of genomic
changes: gene duplication (and loss) that shape families of paralogous genes and …