Selection of the T cell repertoire
E Sebzda, S Mariathasan, T Ohteki… - Annual review of …, 1999 - annualreviews.org
▪ Abstract Advances in gene technology have allowed the manipulation of molecular
interactions that shape the T cell repertoire. Although recognized as fundamental aspects of …
interactions that shape the T cell repertoire. Although recognized as fundamental aspects of …
T-cell signalling and autoimmunity: molecular mechanisms of disease
PS Ohashi - Nature Reviews Immunology, 2002 - nature.com
The genetic manipulation of mice has led to insights into the molecular mechanisms of
autoimmune disease. Recent studies have begun to identify ways in which signalling …
autoimmune disease. Recent studies have begun to identify ways in which signalling …
Autoimmune regulator is expressed in the cells regulating immune tolerance in thymus medulla
M Heino, P Peterson, J Kudoh, K Nagamine… - Biochemical and …, 1999 - Elsevier
The AIRE gene (a utoi mmunere gulator), coding for a putative transcriptional regulatory
factor, is mutated in autoimmune-polyendocrinopathy-candidiasis ectodermal dystrophy …
factor, is mutated in autoimmune-polyendocrinopathy-candidiasis ectodermal dystrophy …
RNA and protein expression of the murine autoimmune regulator gene (Aire) in normal, RelB‐deficient and in NOD mouse
Mutations in the putative transcription factor autoimmune regulator (AIRE) gene are
responsible for autoimmune polyendocrinopathy‐candidiosis‐ectodermal dystrophy …
responsible for autoimmune polyendocrinopathy‐candidiosis‐ectodermal dystrophy …
Thymic commitment of regulatory T cells is a pathway of TCR-dependent selection that isolates repertoires undergoing positive or negative selection
The seminal work of Le Douarin and colleagues (Ohki et al. 1987; Ohki et al. 1988; Salaun
et al. 1990; Coutinho et al. 1993) first demonstrated that peripheral tissue-specific tolerance …
et al. 1990; Coutinho et al. 1993) first demonstrated that peripheral tissue-specific tolerance …
Non-obese diabetic (NOD) mice are genetically susceptible to experimental autoimmune prostatitis (EAP)
VE Rivero, C Cailleau, M Depiante-Depaoli… - Journal of …, 1998 - Elsevier
Rodents develop inflammatory, non-infectious, prostatitis upon autoimmuniz-ation with male
accessory gland (MAG) extracts in complete Freund's adjuvant (CFA). Although there …
accessory gland (MAG) extracts in complete Freund's adjuvant (CFA). Although there …
Animal models of autoimmunity and their relevance to human diseases
S Sakaguchi - Current opinion in immunology, 2000 - Elsevier
T cells mediate various autoimmune diseases. Pathologic autoimmunity can be induced by
manipulating thymic or peripheral control of self-reactive T cells. There is, for example …
manipulating thymic or peripheral control of self-reactive T cells. There is, for example …
Type 1 diabetes pathogenesis and the role of inhibitory receptors in islet tolerance
Abstract Type 1 diabetes (T1D) affects over a million Americans, and disease incidence is
on the rise. Despite decades of research, there is still no cure for this disease. Exciting beta …
on the rise. Despite decades of research, there is still no cure for this disease. Exciting beta …
Immunology in the clinic review series; focus on type 1 diabetes and viruses: enterovirus, thymus and type 1 diabetes pathogenesis
Summary OTHER THEMES PUBLISHED IN THIS IMMUNOLOGY IN THE CLINIC REVIEW
SERIES Metabolic diseases, host responses, cancer, autoinflammatory diseases, allergy …
SERIES Metabolic diseases, host responses, cancer, autoinflammatory diseases, allergy …
Butyrate ameliorates antibiotic-driven type 1 diabetes in the female offspring of nonobese diabetic mice
L Jia, M Cao, H Chen, M Zhang, X Dong… - Journal of agricultural …, 2020 - ACS Publications
Maternal gut dysbiosis affects the development of the offspring immune system. Our
previous study has indicated that microbial metabolite butyrate directly shapes pancreatic …
previous study has indicated that microbial metabolite butyrate directly shapes pancreatic …