Progressive multifocal leukoencephalopathy and other disorders caused by JC virus: clinical features and pathogenesis

CS Tan, IJ Koralnik - The Lancet Neurology, 2010 - thelancet.com
Progressive multifocal leukoencephalopathy (PML) is a rare but often fatal brain disease
caused by reactivation of the polyomavirus JC. Knowledge of the characteristics of PML has …

Molecular biology, epidemiology, and pathogenesis of progressive multifocal leukoencephalopathy, the JC virus-induced demyelinating disease of the human brain

MW Ferenczy, LJ Marshall, CDS Nelson… - Clinical microbiology …, 2012 - Am Soc Microbiol
Progressive multifocal leukoencephalopathy (PML) is a debilitating and frequently fatal
central nervous system (CNS) demyelinating disease caused by JC virus (JCV), for which …

Natalizumab-associated progressive multifocal leukoencephalopathy in patients with multiple sclerosis: lessons from 28 cases

DB Clifford, A DeLuca, DM Simpson, G Arendt… - The Lancet …, 2010 - thelancet.com
Background Treatment of multiple sclerosis with natalizumab is complicated by rare
occurrence of progressive multifocal leukoencephalopathy (PML). Between July, 2006, and …

Progressive multifocal leukoencephalopathy treated by immune checkpoint inhibitors

X Boumaza, B Bonneau, D Roos‐Weil… - Annals of …, 2023 - Wiley Online Library
Objective Our aim was to assess the real‐world effectiveness of immune checkpoint
inhibitors for treatment of patients with progressive multifocal leukoencephalopathy (PML) …

Rituximab-associated progressive multifocal leukoencephalopathy in rheumatoid arthritis

DB Clifford, B Ances, C Costello… - Archives of …, 2011 - jamanetwork.com
Objective To describe the development of progressive multifocal leukoencephalopathy
(PML) in patients with rheumatoid arthritis (RA) treated with rituximab. Design Case study …

HIV-associated opportunistic infections of the CNS

IL Tan, BR Smith, G von Geldern, FJ Mateen… - The Lancet …, 2012 - thelancet.com
Survival in people infected with HIV has improved because of an increasingly powerful array
of antiretroviral treatments, but neurological symptoms due to comorbid conditions, including …

Progressive multifocal leukoencephalopathy and other forms of JC virus disease

BJ Brew, NWS Davies, P Cinque, DB Clifford… - Nature Reviews …, 2010 - nature.com
Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the brain
caused by the JC virus (JCV). PML usually occurs via reactivation of JCV when an immune …

The human JC polyomavirus (JCPyV): virological background and clinical implications

HH Hirsch, P Kardas, D Kranz, C Leboeuf - Apmis, 2013 - Wiley Online Library
JC polyomavirus (JCPyV) was the first of now 12 PyVs detected in humans, when in 1964,
PyV particles were revealed by electron microscopy in progressive multifocal …

Progressive multifocal leukoencephalopathy in transplant recipients

FJ Mateen, RN Muralidharan, M Carone… - Annals of …, 2011 - Wiley Online Library
Objective: Transplant recipients are at risk of develo** progressive multifocal
leukoencephalopathy (PML), a rare demyelinating disorder caused by oligodendrocyte …

Dimethyl fumarate-associated lymphopenia: risk factors and clinical significance

EE Longbrake, RT Naismith, BJ Parks… - Multiple Sclerosis …, 2015 - journals.sagepub.com
Background Dimethyl fumarate (DMF), a disease-modifying therapy for multiple sclerosis
(MS), causes lymphopenia in a fraction of patients. The clinical significance of this is …