People exert large amounts of problem-solving effort playing computer games. Simple
image-and text-recognition tasks have been successfully 'crowd-sourced'through games 1 …

Nuclear magnetic resonance (NMR) spectroscopy is a powerful technique for structural
studies of chemical compounds and biomolecules such as DNA and proteins. Since the …

Nuclear magnetic resonance (NMR) spectroscopy is a powerful method for studying the
structure and dynamics of proteins in their native state. For high-resolution NMR structure …

The automated assignment of NOESY cross peaks has become a fundamental technique for
NMR protein structure analysis. A widely used algorithm for this purpose is implemented in …

Protein-folding intermediates have been implicated in amyloid fibril formation involved in
neurodegenerative disorders. However, the structural mechanisms by which intermediates …

Something fundamental to computation-based research has really changed in the last ten
years. In certain fields, progress is simply dramatically more rapid than previously …

Recent advances in molecular modeling of protein structures are changing the field of
structural biology. AlphaFold-2 (AF2), an AI system developed by DeepMind, Inc., utilizes …

Chemical shifts are highly sensitive probes harnessed by NMR spectroscopists and
structural biologists as conformational parameters to characterize a range of biological …

We present a suite of programs, named CING for Common Interface for NMR Structure
Generation that provides for a residue-based, integrated validation of the structural NMR …

We have found that refinement of protein NMR structures using Rosetta with experimental
NMR restraints yields more accurate protein NMR structures than those that have been …