The alarming escalation of infectious diseases resistant to conventional antibiotics requires
urgent global actions, including the development of new therapeutics. Antimicrobial peptides …

Antimicrobial peptides (AMPs) are part of the armament that insects have developed to fight
off pathogens. Insect AMPs are typically cationic and often made of less than 100 amino acid …

We report the isolation and characterization of a novel human peptide with antimicrobial
activity, termed LEAP-1 (liver-expressed antimicrobial peptide). Using a mass spectrometric …

Mosquito-borne diseases are responsible for significant human morbidity and mortality
throughout the world. Efforts to control mosquito-borne diseases have been impeded, in …

The innate immune response of insects provides a robust line of defense against pathogenic
microbes and eukaryotic parasites. It consists of two types of overlap** immune …

Antimicrobial peptides from a wide spectrum of insects possess potent microbicidal
properties against microbial-related diseases. In this study, seven new gene fragments of …

We have isolated two Drosophila lines that carry point mutations in the gene coding for the
NF-κB-like factor DIF. Like mutants of the Toll pathway, Dif mutant flies are susceptible to …

Two novel antimicrobial peptides, which we propose to name termicin and spinigerin, have
been isolated from the fungus-growing termite Pseudacanthotermes spiniger …

The antimicrobial, insecticidal, and hemolytic properties of peptides isolated from the venom
of the predatory ant Pachycondyla goeldii, a member of the subfamily Ponerinae, were …

We have generated, by ethylmethane sulfonate mutagenesis, loss-of-function mutants in the
Drosophila homolog of the mammalian I-κB kinase (IKK) complex component IKKγ (also …