[HTML][HTML] Physiological regulation of Akt activity and stability
Y Liao, MC Hung - American journal of translational research, 2010 - ncbi.nlm.nih.gov
The serine/threonine protein kinase B (PKB, also known as Akt) constitutes an important
node in diverse signaling cascades downstream of growth factor receptor tyrosine kinases …
node in diverse signaling cascades downstream of growth factor receptor tyrosine kinases …
Signaling pathways in breast cancer: therapeutic targeting of the microenvironment
Breast cancer is the most common cancer in women worldwide. Understanding the biology
of this malignant disease is a prerequisite for selecting an appropriate treatment. Cell cycle …
of this malignant disease is a prerequisite for selecting an appropriate treatment. Cell cycle …
Osteopontin promotes vascular endothelial growth factor–dependent breast tumor growth and angiogenesis via autocrine and paracrine mechanisms
Angiogenesis is the hallmark of cancer, and development of aggressiveness of primary
tumor depends on de novo angiogenesis. Here, using multiple in vitro and in vivo models …
tumor depends on de novo angiogenesis. Here, using multiple in vitro and in vivo models …
Role of phosphatidylinositol 3′-kinase/AKT pathway in diffuse large B-cell lymphoma survival
Abstract Phosphatidylinositol 3′-kinase (PI3K) is a key player in cell-growth signaling in a
number of lymphoid malignancies, but its role in diffuse large B-cell lymphoma (DLBCL) has …
number of lymphoid malignancies, but its role in diffuse large B-cell lymphoma (DLBCL) has …
Cadmium induces mitogenic signaling in breast cancer cell by an ERα-dependent mechanism
M Brama, L Gnessi, S Basciani, N Cerulli, L Politi… - Molecular and cellular …, 2007 - Elsevier
Breast cancer (BC) is linked to estrogen exposure. Estradiol (E2) stimulates BC cells
proliferation by binding the estrogen receptor (ER). Hormone-related cancers have been …
proliferation by binding the estrogen receptor (ER). Hormone-related cancers have been …
Elevated phosphorylation and activation of PDK-1/AKT pathway in human breast cancer
HJ Lin, FC Hsieh, H Song, J Lin - British journal of cancer, 2005 - nature.com
Activation of kinases signalling pathways contributes to various malignant phenotypes in
human cancers, including breast tumour. To examine the possible activation of these …
human cancers, including breast tumour. To examine the possible activation of these …
Breast tumor kinase (protein tyrosine kinase 6) regulates heregulin-induced activation of ERK5 and p38 MAP kinases in breast cancer cells
Total tyrosine kinase activity is often elevated in both cytosolic and membrane fractions of
malignant breast tissue and correlates with a decrease in disease-free survival. Breast tumor …
malignant breast tissue and correlates with a decrease in disease-free survival. Breast tumor …
Tyrosine phosphorylation of sam68 by breast tumor kinase regulates intranuclear localization and cell cycle progression
The breast tumor kinase (BRK) is a growth promoting non-receptor tyrosine kinase
overexpressed in the majority of human breast tumors. BRK is known to potentiate the …
overexpressed in the majority of human breast tumors. BRK is known to potentiate the …
Building a better understanding of the intracellular tyrosine kinase PTK6—BRK by BRK
Protein tyrosine kinase 6 (PTK6), also referred to as breast tumor kinase BRK, is a member
of a distinct family of kinases that is evolutionarily related to the SRC family of tyrosine …
of a distinct family of kinases that is evolutionarily related to the SRC family of tyrosine …
Breast tumor kinase and extracellular signal-regulated kinase 5 mediate Met receptor signaling to cell migration in breast cancer cells
NE Castro, CA Lange - Breast Cancer Research, 2010 - Springer
Abstract Introduction Breast tumor kinase (Brk/protein tyrosine kinase 6 (PTK6)) is a
nonreceptor, soluble tyrosine kinase overexpressed in the majority of breast tumors …
nonreceptor, soluble tyrosine kinase overexpressed in the majority of breast tumors …