Histidine, a versatile proteinogenic amino acid, plays a broad range of roles in all living
organisms and behaves as a key mediator of the interactions of biomolecules with inorganic …

Stimuli-responsive drug delivery systems based on polymeric nanovehicles are among the
most promising treatment regimens for malignant cancers. Such intelligent systems that …

Sustained and intense inflammation is the pathological basis for intervertebral disc
degeneration (IVDD). Effective antagonism or reduction of local inflammatory factors may …

microRNAs (miRs) are emerging as attractive therapeutic targets because of their small size,
specific targetability, and critical role in disease pathogenesis. However,< 20 miR targeting …

RNA therapeutics have emerged as next-generation therapy for the treatment of many
diseases. Unlike small molecules, RNA targeted drugs are not limited by the availability of …

Glioblastoma (GBM) is one of the most lethal malignancies with poor survival and high
recurrence rates. Here, we aimed to simultaneously target oncomiRs 10b and 21, reported …

We explore the potential of clamp-G nucleobase-modified peptide nucleic acids (cGPNAs)
as microRNA and messenger RNA inhibitors. For proof of concept, we target miR-155, which …

Melanin is a brown-black pigment with significant roles in various biological processes. The
tyrosinase enzyme catalyzes the conversion of tyrosine to melanin and has promising uses …

Pancreatic ductal adenocarcinoma (PDAC) is one of the most recalcitrant cancers due to its
late diagnosis, poor therapeutic response, and highly heterogeneous microenvironment …

Trypanosomiases are a group of tropical diseases that have devastating health and socio-
economic effects worldwide. In humans, these diseases are caused by the pathogenic …