Recent Update on Targeting c-MYC G-Quadruplexes by Small Molecules for Anticancer Therapeutics
Guanine-rich DNA sequences have the propensity to adopt four-stranded tetrahelical G-
quadruplex (G4) structures that are overrepresented in gene promoters. The structural …
quadruplex (G4) structures that are overrepresented in gene promoters. The structural …
Ligand design to acquire specificity to intended G‐quadruplex structures
S Asamitsu, T Bando… - Chemistry–A European …, 2019 - Wiley Online Library
AG‐quadruplex is a nucleic acid secondary structure that is adopted by guanine‐rich
sequences, and is considered to be relevant in various pharmacological and biological …
sequences, and is considered to be relevant in various pharmacological and biological …
Cell penetrating thiazole peptides inhibit c-MYC expression via site-specific targeting of c-MYC G-quadruplex
The structural differences among different G-quadruplexes provide an opportunity for site-
specific targeting of a particular G-quadruplex structure. However, majority of G-quadruplex …
specific targeting of a particular G-quadruplex structure. However, majority of G-quadruplex …
The application of click chemistry for targeting quadruplex nucleic acids
The Cu (I)-catalyzed azide and alkyne 1, 3-dipolar cycloaddition (CuAAC), commonly known
as the “click reaction”, has emerged as a powerful and versatile synthetic tool that finds a …
as the “click reaction”, has emerged as a powerful and versatile synthetic tool that finds a …
A non-B DNA binding peptidomimetic channel alters cellular functions
DNA binding transcription factors possess the ability to interact with lipid membranes to
construct ion-permeable pathways. Herein, we present a thiazole-based DNA binding …
construct ion-permeable pathways. Herein, we present a thiazole-based DNA binding …
Mitochondrial G-quadruplex targeting probe with near-infrared fluorescence emission
LL Li, HR Xu, K Li, Q Yang, SL Pan, XQ Yu - Sensors and Actuators B …, 2019 - Elsevier
A novel thiazole orange based fluorescent probe NCT has been reported with promising G-
quadruplex targeting ability. Interacting with G-quadruplexes will enhance its fluorescence …
quadruplex targeting ability. Interacting with G-quadruplexes will enhance its fluorescence …
Targeting Promoter G‐Quadruplex DNAs by Indenopyrimidine‐Based Ligands
The formation of G‐quadruplex structures can regulate telomerase activity and the
expression of oncogenes at the transcriptional and translational levels. Therefore …
expression of oncogenes at the transcriptional and translational levels. Therefore …
Fluorescent Dansyl‐Guanosine Conjugates that Bind c‐MYC Promoter G‐Quadruplex and Downregulate c‐MYC Expression
The four‐stranded G‐quadruplex present in the c‐MYC P1 promoter has been shown to play
a pivotal role in the regulation of c‐MYC transcription. Small‐molecule compounds capable …
a pivotal role in the regulation of c‐MYC transcription. Small‐molecule compounds capable …
A bichromophoric squaraine based NIR fluorescent probe for G-quadruplex in living cells
L Rong, J Cao, Y Dai, W Chen, N Fu - Dyes and Pigments, 2024 - Elsevier
The polymorphic formation of G-quadruplex brings more attentions, because changes of
formation sites affect many physiological processes, like telomere maintenance …
formation sites affect many physiological processes, like telomere maintenance …
Microwave-assisted synthesis of ruthenium (II) complexes with alkynes as potential inhibitor by selectively recognizing c-myc G-quadruplex DNA
S Zhang, Q Wu, H Zhang, Q Wang, X Wang… - Journal of Inorganic …, 2017 - Elsevier
Herein, two polypyridyl ruthenium (II) complexes with alkynes,[Ru (bpy) 2 L](ClO 4) 2 (L= p-
TEPIP (1) and p-BEPIP (2); bpy= 2, 2′-bipyridine; p-TEPIP= 2-(4-trimethylsilylpropargyl)-1H …
TEPIP (1) and p-BEPIP (2); bpy= 2, 2′-bipyridine; p-TEPIP= 2-(4-trimethylsilylpropargyl)-1H …