Clathrin-mediated endocytosis (CME) is the major endocytic pathway in mammalian cells. It
is responsible for the uptake of transmembrane receptors and transporters, for remodeling …

Dynamin, the founding member of a family of dynamin-like proteins (DLPs) implicated in
membrane remodelling, has a critical role in endocytic membrane fission events. The use of …

Diarthrodial joints are essential for load bearing and locomotion. Physiologically, articular
cartilage sustains millions of cycles of mechanical loading. Chondrocytes, the cells in …

Two parameters of biological membranes, curvature and lipid composition, direct the
recruitment of many peripheral proteins to cellular organelles. Although these traits are often …

Biological membranes undergo constant remodeling by membrane fission and fusion to
change their shape and to exchange material between subcellular compartments. During …

Membrane fission, which facilitates compartmentalization of biological processes into
discrete, membrane-bound volumes, is essential for cellular life. Proteins with specific …

Cell surface receptor uptake via clathrin-mediated endocytosis (CME) and subsequent
intracellular sorting for degradation or recycling regulates the strength and specificity of …

Phospholipid membranes form cellular barriers but need to be flexible enough to divide by
fission. Phospholipids generally contain a saturated fatty acid (FA) at position sn1 whereas …

Dynamin mediates fission of vesicles from the plasma membrane during endocytosis.
Typically, dynamin is recruited from the cytosol to endocytic sites, requiring seconds to tens …

Dynamin superfamily proteins (DSPs) mediate membrane fission and fusion necessary for
endocytosis, organelle biogenesis and maintenance, as well as for bacterial cytokinesis …