The packaging of DNA into strings of nucleosomes is one of the features that allows
eukaryotic cells to tightly regulate gene expression. The ordered disassembly of …

Organisms require an appropriate balance of stability and reversibility in gene expression
programmes to maintain cell identity or to enable responses to stimuli; epigenetic regulation …

An RNA-involved phase-separation model has been proposed for transcription control.
However, the molecular links that connect RNA to the transcription machinery remain …

Chromatin is not an inert structure, but rather an instructive DNA scaffold that can respond to
external cues to regulate the many uses of DNA. A principle component of chromatin that …

Cellular differentiation is, by definition, epigenetic. Genome-wide profiling of pluripotent cells
and differentiated cells suggests global chromatin remodelling during differentiation, which …

Histone side chains are post-translationally modified at multiple sites, including at Lys36 on
histone H3 (H3K36). Several enzymes from yeast and humans, including the …

Context-dependent dynamic histone modifications constitute a key epigenetic mechanism in
gene regulation,,–. The Rpd3 small (Rpd3S) complex recognizes histone H3 trimethylation …

Histone modifications not only play important roles in regulating chromatin structure and
nuclear processes but also can be passed to daughter cells as epigenetic marks …

The zinc-dependent mammalian histone deacetylase (HDAC) family comprises 11 enzymes,
which have specific and critical functions in development and tissue homeostasis. Mounting …

Histones comprise the major protein component of chromatin, the scaffold in which the
eukaryotic genome is packaged, and are subject to many types of post-translational …