Unlocking the electrochemical functions of biomolecular condensates

Y Dai, ZG Wang, RN Zare - Nature Chemical Biology, 2024 - nature.com
Biomolecular condensation is a key mechanism for organizing cellular processes in a
spatiotemporal manner. The phase-transition nature of this process defines a density …

Label-free techniques for probing biomolecular condensates

KA Ibrahim, AS Naidu, H Miljkovic, A Radenovic… - ACS …, 2024 - ACS Publications
Biomolecular condensates play important roles in a wide array of fundamental biological
processes, such as cellular compartmentalization, cellular regulation, and other biochemical …

Sequence-dependent material properties of biomolecular condensates and their relation to dilute phase conformations

D Sundaravadivelu Devarajan, J Wang… - Nature …, 2024 - nature.com
Material properties of phase-separated biomolecular condensates, enriched with disordered
proteins, dictate many cellular functions. Contrary to the progress made in understanding the …

Biomolecular condensates are characterized by interphase electric potentials

AE Posey, A Bremer, NA Erkamp, A Pant… - Journal of the …, 2024 - ACS Publications
Biomolecular condensates form via processes that combine phase separation and
reversible associations of multivalent macromolecules. Condensates can be two-or …

RNA-driven phase transitions in biomolecular condensates

GM Wadsworth, S Srinivasan, LB Lai, M Datta… - Molecular Cell, 2024 - cell.com
RNAs and RNA-binding proteins can undergo spontaneous or active condensation into
phase-separated liquid-like droplets. These condensates are cellular hubs for various …

[HTML][HTML] Direct computations of viscoelastic moduli of biomolecular condensates

SR Cohen, PR Banerjee, RV Pappu - The Journal of Chemical Physics, 2024 - pubs.aip.org
Biomolecular condensates are viscoelastic materials defined by time-dependent, sequence-
specific complex shear moduli. Here, we show that viscoelastic moduli can be computed …

Molecular determinants of condensate composition

AS Holehouse, S Alberti - Molecular cell, 2025 - cell.com
Cells use membraneless compartments to organize their interiors, and recent research has
begun to uncover the molecular principles underlying their assembly. Here, we explore how …

Molecular drivers of aging in biomolecular condensates: Desolvation, rigidification, and sticker lifetimes

S Biswas, DA Potoyan - PRX life, 2024 - APS
Biomolecular condensates are dynamic intracellular entities defined by their sequence-and
composition-encoded material properties. During aging, these properties can change …

Metastable Liquid–Liquid Phase Separation and Aging Lead to Strong Processing Path Dependence in Mini‐Spidroin Solutions

D Fedorov, FE Sammalisto, AL Harmat… - Advanced Functional …, 2024 - Wiley Online Library
Recombinant silk proteins provide a route toward sustainable and biocompatible materials.
For making such materials, the assembly process from dilute protein into a functional …

Metastable condensates suppress conversion to amyloid fibrils

T Das, F Zaidi, M Farag, KM Ruff, J Messing… - …, 2024 - pmc.ncbi.nlm.nih.gov
Stress granules form via co-condensation of RNA binding proteins with prion-like low
complexity domains (PLCDs) and RNA molecules released by stress-induced polysomal …