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Unlocking the electrochemical functions of biomolecular condensates
Biomolecular condensation is a key mechanism for organizing cellular processes in a
spatiotemporal manner. The phase-transition nature of this process defines a density …
spatiotemporal manner. The phase-transition nature of this process defines a density …
Label-free techniques for probing biomolecular condensates
Biomolecular condensates play important roles in a wide array of fundamental biological
processes, such as cellular compartmentalization, cellular regulation, and other biochemical …
processes, such as cellular compartmentalization, cellular regulation, and other biochemical …
Sequence-dependent material properties of biomolecular condensates and their relation to dilute phase conformations
Material properties of phase-separated biomolecular condensates, enriched with disordered
proteins, dictate many cellular functions. Contrary to the progress made in understanding the …
proteins, dictate many cellular functions. Contrary to the progress made in understanding the …
Biomolecular condensates are characterized by interphase electric potentials
Biomolecular condensates form via processes that combine phase separation and
reversible associations of multivalent macromolecules. Condensates can be two-or …
reversible associations of multivalent macromolecules. Condensates can be two-or …
RNA-driven phase transitions in biomolecular condensates
RNAs and RNA-binding proteins can undergo spontaneous or active condensation into
phase-separated liquid-like droplets. These condensates are cellular hubs for various …
phase-separated liquid-like droplets. These condensates are cellular hubs for various …
[HTML][HTML] Direct computations of viscoelastic moduli of biomolecular condensates
Biomolecular condensates are viscoelastic materials defined by time-dependent, sequence-
specific complex shear moduli. Here, we show that viscoelastic moduli can be computed …
specific complex shear moduli. Here, we show that viscoelastic moduli can be computed …
Molecular determinants of condensate composition
Cells use membraneless compartments to organize their interiors, and recent research has
begun to uncover the molecular principles underlying their assembly. Here, we explore how …
begun to uncover the molecular principles underlying their assembly. Here, we explore how …
Molecular drivers of aging in biomolecular condensates: Desolvation, rigidification, and sticker lifetimes
Biomolecular condensates are dynamic intracellular entities defined by their sequence-and
composition-encoded material properties. During aging, these properties can change …
composition-encoded material properties. During aging, these properties can change …
Metastable Liquid–Liquid Phase Separation and Aging Lead to Strong Processing Path Dependence in Mini‐Spidroin Solutions
D Fedorov, FE Sammalisto, AL Harmat… - Advanced Functional …, 2024 - Wiley Online Library
Recombinant silk proteins provide a route toward sustainable and biocompatible materials.
For making such materials, the assembly process from dilute protein into a functional …
For making such materials, the assembly process from dilute protein into a functional …
Metastable condensates suppress conversion to amyloid fibrils
Stress granules form via co-condensation of RNA binding proteins with prion-like low
complexity domains (PLCDs) and RNA molecules released by stress-induced polysomal …
complexity domains (PLCDs) and RNA molecules released by stress-induced polysomal …