Introduction Variants in the leucine-rich repeat kinase 2 gene (LRRK2) are risk factors for
Parkinson's disease (PD), but their prevalence varies geographically, reflecting the locations …

Tetrahydrobiopterin (BH 4) deficiency is caused by genetic variants in the three genes
involved in de novo cofactor biosynthesis, GTP cyclohydrolase I (GTPCH/GCH1), 6-pyruvoyl …

Background The dysfunction of immune system and inflammation contribute to the
Parkinson's disease (PD) pathogenesis. Cytokines, oxidative stress, neurotoxin and …

Parkinson's disease (PD) is a heterogenous neurodegenerative disorder. Genetic factors
play a significant role, especially in early onset and familial cases. Mutations are usually …

Sepiapterin reductase, a homodimer composed of two subunits, plays an important role in
the biosynthesis of tetrahydrobiopterin. Furthermore, sepiapterin reductase exhibits a wide …

Abstract Parkinson's disease (PD), a common neurodegenerative disorder, has a complex
etiology where environmental and genetic factors intervene. While a number of genes and …

Abstract The 5, 10-methylenetetrahydrofolate reductase (MTHFR) gene has been reported
to be a candidate gene for susceptibility to Parkinson's disease (PD), but results of different …

Dihydropteridine reductase (QDPR) plays an important role in the recycling of BH4 and is
closely related to oxidative stress. We have previously reported that the overexpression of …

Study objectives The aim was to investigate the association between ZNF184 and symptoms
of Parkinson's disease (PD) in southern Chinese. Methods A total of 241 PD patients were …

Folate metabolism plays quite a critical role in Parkinson's disease (PD). Previous published
research works have studied the link existing between the folate metabolism genetic …