Mouse genome informatics (MGI) resource: genetic, genomic, and biological knowledgebase for the laboratory mouse
JT Eppig - ILAR journal, 2017 - academic.oup.com
Abstract The Mouse Genome Informatics (MGI) Resource supports basic, translational, and
computational research by providing high-quality, integrated data on the genetics …
computational research by providing high-quality, integrated data on the genetics …
The genetics of bone mass and susceptibility to bone diseases
Osteoporosis is characterized by low bone mass and an increased risk of fracture. Genetic
factors, environmental factors and gene–environment interactions all contribute to a person's …
factors, environmental factors and gene–environment interactions all contribute to a person's …
Genome-wide associations reveal human-mouse genetic convergence and modifiers of myogenesis, CPNE1 and STC2
Muscle bulk in adult healthy humans is highly variable even after height, age, and sex are
accounted for. Low muscle mass, due to fewer and/or smaller constituent muscle fibers …
accounted for. Low muscle mass, due to fewer and/or smaller constituent muscle fibers …
Genome wide association analysis in a mouse advanced intercross line
Abstract The LG/J x SM/J advanced intercross line of mice (LG x SM AIL) is a
multigenerational outbred population. High minor allele frequencies, a simple genetic …
multigenerational outbred population. High minor allele frequencies, a simple genetic …
Genetic, epigenetic, and environmental mechanisms govern allele-specific gene expression
CLS Pierre, JF Macias-Velasco, JP Wayhart… - Genome …, 2022 - genome.cshlp.org
Allele-specific expression (ASE) is a phenomenon in which one allele is preferentially
expressed over the other. Genetic and epigenetic factors cause ASE by altering the final …
expressed over the other. Genetic and epigenetic factors cause ASE by altering the final …
Parent-of-origin effects propagate through networks to shape metabolic traits
JF Macias-Velasco, CL St Pierre, JP Wayhart, L Yin… - Elife, 2022 - elifesciences.org
Parent-of-origin effects are unexpectedly common in complex traits, including metabolic and
neurological traits. Parent-of-origin effects can be modified by the environment, but the …
neurological traits. Parent-of-origin effects can be modified by the environment, but the …
Whole exome sequencing of wild-derived inbred strains of mice improves power to link phenotype and genotype
The house mouse is a powerful model to dissect the genetic basis of phenotypic variation,
and serves as a model to study human diseases. Despite a wealth of discoveries, most …
and serves as a model to study human diseases. Despite a wealth of discoveries, most …
Genetic architecture of trait variance in craniofacial morphology
The genetic architecture of trait variance has long been of interest in genetics and evolution.
One of the earliest attempts to understand this architecture was presented in Lerner's …
One of the earliest attempts to understand this architecture was presented in Lerner's …
Physiologic and genetic evidence links hemopexin to triglycerides in mice and humans
Results: HPX expression in mouse adipose tissue, but not in liver, was regulated by dietary
fat regardless of genetic background. HPX increased in concert with adipogenesis in 3T3-L1 …
fat regardless of genetic background. HPX increased in concert with adipogenesis in 3T3-L1 …
Evolution of parent-of-origin effects on placental gene expression in house mice
The mammalian placenta is a hotspot for the evolution of genomic imprinting, a form of gene
regulation that involves the parent-specific epigenetic silencing of one allele. Imprinted …
regulation that involves the parent-specific epigenetic silencing of one allele. Imprinted …