Navigating the pitfalls of applying machine learning in genomics

S Whalen, J Schreiber, WS Noble… - Nature Reviews Genetics, 2022 - nature.com
The scale of genetic, epigenomic, transcriptomic, cheminformatic and proteomic data
available today, coupled with easy-to-use machine learning (ML) toolkits, has propelled the …

Network propagation: a universal amplifier of genetic associations

L Cowen, T Ideker, BJ Raphael, R Sharan - Nature Reviews Genetics, 2017 - nature.com
Biological networks are powerful resources for the discovery of genes and genetic modules
that drive disease. Fundamental to network analysis is the concept that genes underlying the …

Graph neural networks: foundation, frontiers and applications

L Wu, P Cui, J Pei, L Zhao, X Guo - … of the 28th ACM SIGKDD Conference …, 2022 - dl.acm.org
The field of graph neural networks (GNNs) has seen rapid and incredible strides over the
recent years. Graph neural networks, also known as deep learning on graphs, graph …

Structure-based protein function prediction using graph convolutional networks

V Gligorijević, PD Renfrew, T Kosciolek… - Nature …, 2021 - nature.com
The rapid increase in the number of proteins in sequence databases and the diversity of
their functions challenge computational approaches for automated function prediction. Here …

Machine learning applications in genetics and genomics

MW Libbrecht, WS Noble - Nature Reviews Genetics, 2015 - nature.com
The field of machine learning, which aims to develop computer algorithms that improve with
experience, holds promise to enable computers to assist humans in the analysis of large …

Machine learning in medicine

RC Deo - Circulation, 2015 - Am Heart Assoc
Spurred by advances in processing power, memory, storage, and an unprecedented wealth
of data, computers are being asked to tackle increasingly complex learning tasks, often with …

The GeneMANIA prediction server: biological network integration for gene prioritization and predicting gene function

D Warde-Farley, SL Donaldson, O Comes… - Nucleic acids …, 2010 - academic.oup.com
Abstract GeneMANIA (http://www. genemania. org) is a flexible, user-friendly web interface
for generating hypotheses about gene function, analyzing gene lists and prioritizing genes …

Characterizing the replicability of cell types defined by single cell RNA-sequencing data using MetaNeighbor

M Crow, A Paul, S Ballouz, ZJ Huang, J Gillis - Nature communications, 2018 - nature.com
Single-cell RNA-sequencing (scRNA-seq) technology provides a new avenue to discover
and characterize cell types; however, the experiment-specific technical biases and analytic …

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts

AG Baltz, M Munschauer, B Schwanhäusser, A Vasile… - Molecular cell, 2012 - cell.com
Protein-RNA interactions are fundamental to core biological processes, such as mRNA
splicing, localization, degradation, and translation. We developed a photoreactive …

GeneMANIA Cytoscape plugin: fast gene function predictions on the desktop

J Montojo, K Zuberi, H Rodriguez, F Kazi… - …, 2010 - academic.oup.com
The GeneMANIA Cytoscape plugin brings fast gene function prediction capabilities to the
desktop. GeneMANIA identifies the most related genes to a query gene set using a guilt-by …