Navigating the pitfalls of applying machine learning in genomics
The scale of genetic, epigenomic, transcriptomic, cheminformatic and proteomic data
available today, coupled with easy-to-use machine learning (ML) toolkits, has propelled the …
available today, coupled with easy-to-use machine learning (ML) toolkits, has propelled the …
Network propagation: a universal amplifier of genetic associations
Biological networks are powerful resources for the discovery of genes and genetic modules
that drive disease. Fundamental to network analysis is the concept that genes underlying the …
that drive disease. Fundamental to network analysis is the concept that genes underlying the …
Graph neural networks: foundation, frontiers and applications
The field of graph neural networks (GNNs) has seen rapid and incredible strides over the
recent years. Graph neural networks, also known as deep learning on graphs, graph …
recent years. Graph neural networks, also known as deep learning on graphs, graph …
Structure-based protein function prediction using graph convolutional networks
The rapid increase in the number of proteins in sequence databases and the diversity of
their functions challenge computational approaches for automated function prediction. Here …
their functions challenge computational approaches for automated function prediction. Here …
Machine learning applications in genetics and genomics
The field of machine learning, which aims to develop computer algorithms that improve with
experience, holds promise to enable computers to assist humans in the analysis of large …
experience, holds promise to enable computers to assist humans in the analysis of large …
Machine learning in medicine
RC Deo - Circulation, 2015 - Am Heart Assoc
Spurred by advances in processing power, memory, storage, and an unprecedented wealth
of data, computers are being asked to tackle increasingly complex learning tasks, often with …
of data, computers are being asked to tackle increasingly complex learning tasks, often with …
The GeneMANIA prediction server: biological network integration for gene prioritization and predicting gene function
D Warde-Farley, SL Donaldson, O Comes… - Nucleic acids …, 2010 - academic.oup.com
Abstract GeneMANIA (http://www. genemania. org) is a flexible, user-friendly web interface
for generating hypotheses about gene function, analyzing gene lists and prioritizing genes …
for generating hypotheses about gene function, analyzing gene lists and prioritizing genes …
Characterizing the replicability of cell types defined by single cell RNA-sequencing data using MetaNeighbor
Single-cell RNA-sequencing (scRNA-seq) technology provides a new avenue to discover
and characterize cell types; however, the experiment-specific technical biases and analytic …
and characterize cell types; however, the experiment-specific technical biases and analytic …
The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts
AG Baltz, M Munschauer, B Schwanhäusser, A Vasile… - Molecular cell, 2012 - cell.com
Protein-RNA interactions are fundamental to core biological processes, such as mRNA
splicing, localization, degradation, and translation. We developed a photoreactive …
splicing, localization, degradation, and translation. We developed a photoreactive …
GeneMANIA Cytoscape plugin: fast gene function predictions on the desktop
J Montojo, K Zuberi, H Rodriguez, F Kazi… - …, 2010 - academic.oup.com
The GeneMANIA Cytoscape plugin brings fast gene function prediction capabilities to the
desktop. GeneMANIA identifies the most related genes to a query gene set using a guilt-by …
desktop. GeneMANIA identifies the most related genes to a query gene set using a guilt-by …