Membrane active antimicrobial peptides: translating mechanistic insights to design
J Li, JJ Koh, S Liu, R Lakshminarayanan… - Frontiers in …, 2017 - frontiersin.org
Antimicrobial peptides (AMPs) are promising next generation antibiotics that hold great
potential for combating bacterial resistance. AMPs can be both bacteriostatic and …
potential for combating bacterial resistance. AMPs can be both bacteriostatic and …
The role of lipids in Parkinson's disease
H **coy, B Wieringa, GJM Martens - Cells, 2019 - mdpi.com
Parkinson's disease (PD) is a neurodegenerative disease characterized by a progressive
loss of dopaminergic neurons from the nigrostriatal pathway, formation of Lewy bodies, and …
loss of dopaminergic neurons from the nigrostriatal pathway, formation of Lewy bodies, and …
Structural and molecular modelling studies reveal a new mechanism of action of chloroquine and hydroxychloroquine against SARS-CoV-2 infection
The recent emergence of the novel pathogenic SARS-coronavirus 2 (SARS-CoV-2) is
responsible for a worldwide pandemic. Given the global health emergency, drug …
responsible for a worldwide pandemic. Given the global health emergency, drug …
Lipid-chaperone hypothesis: A common molecular mechanism of membrane disruption by intrinsically disordered proteins
An increasing number of human diseases has been shown to be linked to aggregation and
amyloid formation by intrinsically disordered proteins (IDPs). Amylin, amyloid-β, and α …
amyloid formation by intrinsically disordered proteins (IDPs). Amylin, amyloid-β, and α …
α-synuclein interacts with PrPC to induce cognitive impairment through mGluR5 and NMDAR2B
DG Ferreira, M Temido-Ferreira… - Nature …, 2017 - nature.com
Synucleinopathies, such as Parkinson's disease and dementia with Lewy bodies, are
neurodegenerative disorders that are characterized by the accumulation of α-synuclein …
neurodegenerative disorders that are characterized by the accumulation of α-synuclein …
Simulation studies of amyloidogenic polypeptides and their aggregates
Amyloids, fibrillar assembly of (poly) peptide chains, are associated with neurodegenerative
illnesses such as Alzheimer's and Parkinson's diseases, for which there are no cures. The …
illnesses such as Alzheimer's and Parkinson's diseases, for which there are no cures. The …
Role of copper in the onset of Alzheimer's disease compared to other metals
Alzheimer's disease (AD) is a neurodegenerative disorder that is characterized by amyloid
plaques in patients' brain tissue. The plaques are mainly made of β-amyloid peptides and …
plaques in patients' brain tissue. The plaques are mainly made of β-amyloid peptides and …
Synergistic antiviral effect of hydroxychloroquine and azithromycin in combination against SARS-CoV-2: What molecular dynamics studies of virus-host interactions …
The emergence of SARS-coronavirus-2 (SARS-CoV-2) has led to a global pandemic
disease referred to as coronavirus disease 19 (COVID-19). Hydroxychloroquine (CLQ …
disease referred to as coronavirus disease 19 (COVID-19). Hydroxychloroquine (CLQ …
Copper toxicity links to pathogenesis of Alzheimer's disease and therapeutics approaches
HW Ejaz, W Wang, M Lang - International Journal of Molecular Sciences, 2020 - mdpi.com
Alzheimer's disease (AD) is an irreversible, age-related progressive neurological disorder,
and the most common type of dementia in aged people. Neuropathological lesions of AD …
and the most common type of dementia in aged people. Neuropathological lesions of AD …
Cholesterol as a key player in amyloid β-mediated toxicity in Alzheimer's disease
V Rudajev, J Novotny - Frontiers in molecular neuroscience, 2022 - frontiersin.org
Alzheimer's disease (AD) is a neurodegenerative disorder that is one of the most
devastating and widespread diseases worldwide, mainly affecting the aging population. One …
devastating and widespread diseases worldwide, mainly affecting the aging population. One …