Functional Imaging and Optogenetics in Drosophila

JH Simpson, LL Looger - Genetics, 2018 - academic.oup.com
Understanding how activity patterns in specific neural circuits coordinate an animal's
behavior remains a key area of neuroscience research. Genetic tools and a brain of …

Linking physiological processes and feeding behaviors by octopamine

M Selcho, D Pauls - Current Opinion in Insect Science, 2019 - Elsevier
Highlights•Octopaminergic neurons adapt feeding-relevant behaviors to the physiological
status.•Starvation-induced hyperactivity is mediated by octopamine.•Octopamine acts both …

A comprehensive anatomical map of the peripheral octopaminergic/tyraminergic system of Drosophila melanogaster

D Pauls, C Blechschmidt, F Frantzmann, B El Jundi… - Scientific Reports, 2018 - nature.com
The modulation of an animal's behavior through external sensory stimuli, previous
experience and its internal state is crucial to survive in a constantly changing environment …

Synaptic plasticity induced by differential manipulation of tonic and phasic motoneurons in Drosophila

NA Aponte-Santiago, KG Ormerod… - Journal of …, 2020 - jneurosci.org
Structural and functional plasticity induced by neuronal competition is a common feature of
develo** nervous systems. However, the rules governing how postsynaptic cells …

Synthetic light-activated ion channels for optogenetic activation and inhibition

S Beck, J Yu-Strzelczyk, D Pauls… - Frontiers in …, 2018 - frontiersin.org
Optogenetic manipulation of cells or living organisms became widely used in neuroscience
following the introduction of the light-gated ion channel channelrhodopsin-2 (ChR2). ChR2 …

Structural and functional synaptic plasticity induced by convergent synapse loss in the Drosophila neuromuscular circuit

Y Wang, M Lobb-Rabe, J Ashley, V Anand… - Journal of …, 2021 - jneurosci.org
Throughout the nervous system, the convergence of two or more presynaptic inputs on a
target cell is commonly observed. The question we ask here is to what extent converging …

Biochemical CuSO4 Toxicity in Drosophila melanogaster Depends on Sex and Developmental Stage of Exposure

PT Halmenschelager, JBT da Rocha - Biological trace element research, 2019 - Springer
Copper is a transition metal that exists in different chemical forms (eg, Cu 2+, Cu+, and Cu 0)
and at high concentrations it is toxic. Here, we investigated the Cu 2+-induced toxicity in …

Reward signaling in a recurrent circuit of dopaminergic neurons and peptidergic Kenyon cells

R Lyutova, M Selcho, M Pfeuffer, D Segebarth… - Nature …, 2019 - nature.com
Dopaminergic neurons in the brain of the Drosophila larva play a key role in mediating
reward information to the mushroom bodies during appetitive olfactory learning and …

Dedicated photoreceptor pathways in Drosophila larvae mediate navigation by processing either spatial or temporal cues

TH Humberg, P Bruegger, B Afonso, M Zlatic… - Nature …, 2018 - nature.com
To integrate changing environmental cues with high spatial and temporal resolution is
critical for animals to orient themselves. Drosophila larvae show an effective motor program …

Odor-taste learning in Drosophila larvae

A Widmann, K Eichler, M Selcho, AS Thum… - Journal of insect …, 2018 - Elsevier
The Drosophila larva is an attractive model system to study fundamental questions in the
field of neuroscience. Like the adult fly, the larva offers a seemingly unlimited genetic …