The endothelium is the cell monolayer that lines the interior of the blood vessels separating
the vessel lumen where blood circulates, from the surrounding tissues. During embryonic …

The Zebrafish has emerged to become a powerful vertebrate animal model for
cardiovascular research in recent years. Its advantages include easy genetic manipulation …

Shear stress on arteries produced by blood flow is important for vascular development and
homeostasis but can also initiate atherosclerosis. Endothelial cells that line the vasculature …

Background Flow properties play an important role in cardiac function, remodeling, and
morphogenesis but cannot be displayed in detail with today's echocardiographic …

Mechanotransduction refers to the conversion of mechanical forces into biochemical or
electrical signals that initiate structural and functional remodeling in cells and tissues. The …

Congenital heart disease often features structural abnormalities that emerge during
development. Accumulating evidence indicates a crucial role for cardiac contraction and the …

Cardiac contractions and hemodynamic forces are essential for organ development and
homeostasis. Control over cardiac contractions can be achieved pharmacologically or …

With the term 'mechanotransduction', it is intended the ability of cells to sense and respond
to mechanical forces by activating intracellular signal transduction pathways and the relative …

Organ morphogenesis involves dynamic changes of tissue properties while cells adapt to
their mechanical environment through mechanosensitive pathways. How mechanical cues …