Macrophages are versatile and heterogeneous innate immune cells undertaking central
functions in balancing immune responses and tissue repair to maintain homeostasis. This …

Macrophages are found in tissues, body cavities, and mucosal surfaces. Most tissue
macrophages are seeded in the early embryo before definitive hematopoiesis is …

There have been many chapters written about macrophage polarization. These chapters
generally focus on the role of macrophages in orchestrating immune responses by …

In recent years, a lot of scientific interest has focused on cancer immunotherapy. Although
chronic inflammation has been described as one of the hallmarks of cancer, acute …

Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related death in the
world. Immunological analysis of the tumor microenvironment (immunoscore) shows great …

Long known as digestive organelles, lysosomes have now emerged as multifaceted centers
responsible for degradation, nutrient sensing, and immunity. Growing evidence also …

Toll-like receptors (TLRs) are pattern recognition receptors (PRRs) expressed in various
immune cell types and perform multiple purposes and duties involved in the induction of …

Radiation therapy (RT) activates an in situ vaccine effect when combined with immune
checkpoint blockade (ICB), yet this effect may be limited because RT does not fully optimize …

Cutaneous T cell lymphoma (CTCL) represents a heterogeneous group of non-Hodgkin
lymphoma distinguished by the presence of clonal malignant T cells. The heterogeneity of …

Simple Summary Interferons are cytokines that play key roles in the activation of cellular
components of the immune response, such as dendritic cells, macrophages and T cells …