The enhancement of complex physiological functions such as cognition and exercise
performance in healthy individuals represents a challenging goal. Adaptive transcription …

The complex pathophysiology of Alzheimer's disease (AD) poses challenges for the
development of therapies. Recently, neuroinflammation has been identified as a key …

Melanin-like nanoparticles (MNPs) have recently emerged as valuable agents in antioxidant
therapy due to their excellent biocompatibility and potent capacity to scavenge various …

One of the deadliest types of cancer is pancreatic ductal adenocarcinoma (PDAC). Chronic
stress and obesity are recognized as risk factors for PDAC. We hypothesized that the …

Post-stroke depression (PSD) is one of the most common mental sequelae after a stroke and
can damage the brain. Although PSD has garnered increasing attention in recent years, the …

Although physical exercise has obvious benefits in brain physiology, the molecular
biomarkers induced by exercise protocols are inconclusive. Evidence indicates that exercise …

Depression is a prevalent neuropsychiatric disorder characterized by persistent sadness
and a lack of interest, significantly impacting the quality of life. Icaritin, a bioactive compound …

Our previous in vitro studies showed that excitotoxicity evoked by glutamate analogue
kainate (KA) significantly decreased the number of rat spinal neurons and triggered high …

Orexin–a neuropeptide–is extensively distributed in the central nervous system and is
involved in the regulation of diverse physiological functions and behaviors. Orexin is …

The cAMP response element-binding protein (CREB) is a multifunctional transcription factor
belonging to the basic leucine zipper (bZIP) family of proteins. It regulates the expression of …