Microfluidics, a technology characterized by the engineered manipulation of fluids at the
submillimetre scale, has shown considerable promise for improving diagnostics and biology …

Spatiotemporal control of leukocyte dynamics within tissues is critical for successful innate
and adaptive immune responses. Homeostatic trafficking and coordinated infiltration into …

Successful translation of in vivo experimental data to human patients is an unmet need and
a bottleneck in the development of effective therapeutics. Organ-on-Chip technology aims to …

Microfluidic devices can better control cellular microenvironments compared to conventional
cell migration assays. Over the past few years, microfluidics-based chemotaxis studies …

The transition to increasingly sophisticated microfluidic systems has led to the emergence of
“organ-on-chip” technology that can faithfully recapitulate organ-level function. Given the …

Highlights•Immune system plays a critical role in maintaining homeostasis of the human
body.•Development of immune-system-on-a-chip platforms is in its infancy.•Several …

Leukocyte migration into tissues is characteristic of inflammation. It is usually measured in
vitro as the average displacement of populations of cells towards a chemokine gradient, not …

Vessel geometries in microengineered in vitro vascular models are important to recapitulate
a pathophysiological microenvironment for the study of flow-induced endothelial dysfunction …

Current male fertility diagnosis tests focus on assessing the quality of semen samples by
studying the concentration, total volume, and motility of spermatozoa. However, other …

Finely tuned to respond quickly to infections, neutrophils have amazing abilities to migrate
fast and efficiently towards sites of infection and inflammation. Although neutrophils ability to …