Digital twins for multiple sclerosis

I Voigt, H Inojosa, A Dillenseger, R Haase… - Frontiers in …, 2021 - frontiersin.org
An individualized innovative disease management is of great importance for people with
multiple sclerosis (pwMS) to cope with the complexity of this chronic, multidimensional …

Digital biomarkers in multiple sclerosis

A Dillenseger, ML Weidemann, K Trentzsch, H Inojosa… - Brain sciences, 2021 - mdpi.com
For incurable diseases, such as multiple sclerosis (MS), the prevention of progression and
the preservation of quality of life play a crucial role over the entire therapy period. In MS …

Lesion network localization of depression in multiple sclerosis

SH Siddiqi, I Kletenik, MC Anderson, M Cavallari… - Nature Mental …, 2023 - nature.com
Multiple sclerosis (MS), a demyelinating disease that causes focal white matter lesions, is
commonly associated with depression. However, it remains unclear whether depression risk …

Management of multiple sclerosis fatigue in the digital age: From assessment to treatment

C Pinarello, J Elmers, H Inojosa, C Beste… - Frontiers in …, 2023 - frontiersin.org
Fatigue is one of the most disabling symptoms of Multiple Sclerosis (MS), affecting more
than 80% of patients over the disease course. Nevertheless, it has a multi-faceted and …

No increase in symptoms toward the end of the ocrelizumab infusion cycle in patients with multiple sclerosis: symptom burden on ocrelizumab: a longitudinal study …

I Kister, C Oh, EA Douglas, TE Bacon… - Neurology: Clinical …, 2023 - AAN Enterprises
Background and Objectives Some patients with multiple sclerosis (MS) receiving
ocrelizumab (OCR) report worsening symptoms toward the end of the 6-month infusion cycle …

A novel digital care management platform to monitor clinical and subclinical disease activity in multiple sclerosis

W Van Hecke, L Costers, A Descamps, A Ribbens… - Brain sciences, 2021 - mdpi.com
In multiple sclerosis (MS), the early detection of disease activity or progression is key to
inform treatment changes and could be supported by digital tools. We present a novel CE …

Data collection in multiple sclerosis: the MSDS approach

T Ziemssen, R Kern, I Voigt, R Haase - Frontiers in Neurology, 2020 - frontiersin.org
Multiple sclerosis (MS) is a frequent chronic inflammatory disease of the central nervous
system that affects patients over decades. As the monitoring and treatment of MS become …

Latent structure of a brief clinical battery of neuropsychological tests administered in-home via telephone

A Matchanova, MA Babicz, LD Medina… - Archives of Clinical …, 2021 - academic.oup.com
Objective To examine the factor structure and sociodemographic correlates of a battery of
clinical neuropsychological tests administered in-home and via telephone. Method …

Outcome measures for physical fatigue in individuals with multiple sclerosis: a systematic review

G Sellitto, A Morelli, S Bassano, A Conte… - Expert Review of …, 2021 - Taylor & Francis
Introduction Physical fatigue can be a common reason for early retirement or sick leave
since it appears in the earliest stages of multiple sclerosis (MS). Therefore, a prompt and …

Establishing clinically meaningful within-individual improvement thresholds for eight patient-reported outcome measures in people with relapsing-remitting multiple …

N Greene, S Quéré, DP Bury, F Mazerolle… - Journal of Patient …, 2023 - Springer
Background As disease-modifying therapies do not reverse the course of multiple sclerosis
(MS), assessment of therapeutic success involves documenting patient-reported outcomes …