Most of Earth's prokaryotes live under energy limitation, yet the full breadth of strategies that
enable survival under such conditions remain poorly understood. Here we report the …

The oral cavity harbors a diverse and dynamic bacterial biofilm community which is pivotal to
oral health maintenance and, if turning dysbiotic, can contribute to various diseases …

Tannerella forsythia is an anaerobic, fusiform Gram-negative oral pathogen strongly
associated with periodontitis, a multibacterial inflammatory disease that leads to the …

During growth and division, the bacterial cell wall is remodeled, resulting in the liberation of
peptidoglycan (PG) fragments which are typically reinternalized and recycled. Recycling of …

The bacterial cell wall consists of a three-dimensional peptidoglycan layer, composed of
peptides linked to the sugars N-acetylmuramic acid (MurNAc) and GlcNAc. Unlike other …

The onset and development of periodontitis centers around microbiota dysbiosis and
disrupted host responses. Dynamic metabolic activities of the subgingival microbiota modify …

The recently identified bacterium Tannerella serpentiformis is the closest phylogenetic
relative of Tannerella forsythia, whose presence in oral biofilms is associated with …

The Gram-negative periodontal pathogen Tannerella forsythia is inherently auxotrophic for
N-acetylmuramic acid (MurNAc), which is an essential carbohydrate constituent of the …

The bacterial cell wall is made from peptidoglycan (PG), a heteropolymer which forms a bag-
like exoskeleton that envelopes the cell. PG is constantly remodelled during growth and …