The C. elegans insulin/IGF-1 signaling (IIS) pathway connects nutrient levels to metabolism,
growth, development, longevity, and behavior. This fundamental pathway is regulated by …

Advances in research and technology has increased our quality of life, allowed us to combat
diseases, and achieve increased longevity. Unfortunately, increased longevity is …

Caenorhabditis elegans survives on ephemeral food sources in the wild, and the species
has a variety of adaptive responses to starvation. These features of its life history make the …

Historically, insulin is best known for its role in peripheral glucose homeostasis, and insulin
signaling in the brain has received less attention. Insulin-independent brain glucose uptake …

Learning is an essential biological process for survival since it facilitates behavioural
plasticity in response to environmental changes. This process is mediated by a wide variety …

Gene families expand by gene duplication, and resulting paralogs diverge through mutation.
Functional diversification can include neofunctionalization as well as subfunctionalization of …

Insulin and insulin-like peptides (ILP) help to maintain glucose homeostasis, whereas
insulin-like growth factor (IGF) promotes the growth and differentiation of cells in both …

Alzheimer's disease (AD) is an example of age-related dementia, and there are still no
known preventive or curative measures for this disease. Obesity and associated metabolic …

Internal state alters sensory behaviors to optimize survival strategies. The neuronal
mechanisms underlying hunger-dependent behavioral plasticity are not fully characterized …

Behavioral plasticity allows animals to modulate their behavior based on experience and
environmental conditions. Caenorhabditis elegans exhibits experience-dependent changes …