From embryonic development, postnatal growth and adult homeostasis to reparative and
disease states, cells and tissues undergo constant changes in genome activity, cell fate …

The cellular microenvironment is highly heterogeneous and dynamic. Therefore, cells must
be equipped with molecular tools to adapt and respond to constantly fluctuating inputs. One …

Age‐related macular degeneration (AMD) disease has become a worldwide senile disease,
and frequent intravitreal injection of anti‐vascular endothelial growth factor (anti‐VEGF) is …

The cell nucleus plays a key role in cellular mechanoresponses. 3D genome organisation,
gene expression, and cell behaviour, in general, are affected by mechanical force …

Laminins (LMs) constitute a family of heterotrimeric glycoproteins essential for the formation
of basement membranes (BM). They act as molecular bridges between cells and the …

As a model of the intestinal epithelium, intestinal stem cells (ISCs) are grown and
differentiated as monolayers on materials where stochastic organization of the crypt and villi …

Intermediate filaments (IFs) comprise a large family of versatile cytoskeletal proteins, divided
into six subtypes with tissue-specific expression patterns. IFs have a wide repertoire of …

Biologists have the capability to edit a genome at the nanometer scale and then observe
whether or not the edit affects the structure of a develo** organ or organism at the …

Inspired by massive intermediate filament (IF) reorganization in superstretched epithelia, we
examine computationally the principles controlling the mechanics of a set of entangled …

Cells sense and respond to mechanical forces through mechanotransduction, which
regulates processes in health and disease. In single adhesive cells, mechanotransduction …