Deciphering the sub-compartmental location of a given protein of interest may help explain
its physiological function, but it can be challenging to do using optical or biochemical …

Membrane topology refers to the two-dimensional structural information of a membrane
protein that indicates the number of transmembrane (TM) segments and the orientation of …

Membrane proteins perform a variety of functions, all crucially dependent on their orientation
in the membrane. However, neither the exact number of transmembrane domains (TMDs) …

Viruses maximize their genetic coding capacity through a variety of biochemical
mechanisms, including programmed ribosomal frameshifting (PRF), which facilitates the …

Nascent chains are known to be targeted to the endoplasmic reticulum membrane either by
a signal recognition particle (SRP)-dependent co-translational or by an SRP-independent …

Fluoride is a ubiquitous environmental toxin with which all biological species must cope. A
recently discovered family of fluoride export (FEX) proteins protects organisms from fluoride …

Membrane proteins play pivotal roles in a wide array of cellular processes and constitute
approximately a quarter of the protein-coding genes across all organisms. Despite their …

The split green fluorescent protein (GFP) system was adapted for investigation of the
topology of ER‐associated proteins. A 215‐amino acid fragment of GFP (S1–10) was …

Translocon-associated protein (TRAP) complex is intimately associated with the ER
translocon for the insertion or translocation of newly synthesised proteins in eukaryotic cells …

Membrane proteins of the endoplasmic reticulum (ER) are involved in a wide array of
essential cellular functions. Identification of the topology of membrane proteins can provide …