The aggregation of amyloid-beta peptide and tau protein dysregulation are implicated to
play key roles in Alzheimer's disease pathogenesis and are considered the main …

Gradual degeneration and loss of dopaminergic neurons in the substantia nigra, pars
compacta and subsequent reduction of dopamine levels in striatum are associated with …

Background Increasing evidence supports an extensive and complex genetic contribution to
PD. Previous genome‐wide association studies (GWAS) have shed light on the genetic …

Background GBA1 variants are among the most common genetic risk factors for Parkinson's
disease (PD). GBA1 variants can be classified into three categories based on their role in …

Almost two decades after the identification of SNCA as the first causative gene in
Parkinson's disease (PD) and the subsequent understanding that genetic factors play a …

Objective We hypothesized that specific mutations in the β‐glucocerebrosidase gene (GBA)
causing neuropathic Gaucher's disease (GD) in homozygotes lead to aggressive cognitive …

Importance Parkinson disease (PD) is heterogeneous in symptom manifestation and rate of
progression. Identifying factors that influence disease progression could provide …

Objective To determine if any association between previously identified alleles that confer
risk for Parkinson disease and variables measuring disease progression. Methods We …

Lysosomes have fundamental physiological roles and have previously been implicated in
Parkinson's disease,,,–. However, how extracellular growth factors communicate with …

Background Several reports have identified different patterns of Parkinson's disease
progression in individuals carrying missense variants in GBA or LRRK2 genes. The overall …