Metabolomics is the comprehensive study of small-molecule metabolites. Obtaining a wide
coverage of the metabolome is challenging because of the broad range of physicochemical …

Parasitic helminths have coevolved with humans over millennia, intricately refining and
develo** an array of mechanisms to suppress or skew the host's immune system, thereby …

Schistosomes are long lived, intravascular parasitic platyhelminths that infect> 200 million
people globally. The molecular mechanisms used by these blood flukes to dampen host …

Parasitic helminths secrete and excrete a vast array of molecules known to help skew or
suppress the host's immune response, thereby establishing a niche for sustained parasite …

The molecular mechanisms through which dendritic cells (DCs) prime T helper 2 (Th2)
responses, including those elicited by parasitic helminths, remain incompletely understood …

Metabolic reprogramming is rapidly gaining appreciation in the etiology of immune cell
dysfunction in a variety of diseases. Tuberculosis, schistosomiasis, and sarcoidosis …

Introduction Helminths are parasitic worms that infect millions of people worldwide and
secrete a variety of excretory-secretory products (ESPs), including proteins, peptides, and …

Helminths like Schistosoma mansoni release excretory/secretory (E/S) products that
modulate host immunity to enable infection. Extracellular vesicles (EVs) are among these …

Type 2 immunity is critical for the protective and repair responses that mediate resistance to
parasitic helminth infection. This immune response also drives aberrant inflammation during …

Inflammatory bowel disease (IBD) is associated with a dysregulated mucosal immune
response in the gastrointestinal tract. The number of patients with IBD has increased …