Perfluorinated Iridium Catalyst for Signal Amplification by Reversible Exchange Provides Metal-Free Aqueous Hyperpolarized [1-13C]-Pyruvate
J Ettedgui, B Blackman, N Raju, SA Kotler… - Journal of the …, 2023 - ACS Publications
Hyperpolarized (HP) carbon-13 [13C] enables the specific investigation of dynamic
metabolic and physiologic processes via in vivo MRI-based molecular imaging. As the …
metabolic and physiologic processes via in vivo MRI-based molecular imaging. As the …
MATRESHCA: Microtesla Apparatus for Transfer of Resonance Enhancement of Spin Hyperpolarization via Chemical Exchange and Addition
We present an integrated, open-source device for parahydrogen-based hyperpolarization
processes in the microtesla field regime with a cost of components of less than $7000. The …
processes in the microtesla field regime with a cost of components of less than $7000. The …
Over 20% Carbon-13 Polarization of Perdeuterated Pyruvate Using Reversible Exchange with Parahydrogen and Spin-Lock Induced Crossing at 50 μT
Carbon-13 hyperpolarized pyruvate is about to become the next-generation contrast agent
for molecular magnetic resonance imaging of cancer and other diseases. Here, efficient and …
for molecular magnetic resonance imaging of cancer and other diseases. Here, efficient and …
[HTML][HTML] Hyperpolarised benchtop NMR spectroscopy for analytical applications
Benchtop NMR spectrometers, with moderate magnetic field strengths (B 0= 1− 2. 4 T) and
sub-ppm chemical shift resolution, are an affordable and portable alternative to standard …
sub-ppm chemical shift resolution, are an affordable and portable alternative to standard …
Nuclear spin polarization of lactic acid via exchange of parahydrogen-polarized protons
K Them, J Kuhn, AN Pravdivtsev… - Communications …, 2024 - nature.com
Hyperpolarization has become a powerful tool to enhance the sensitivity of magnetic
resonance. A universal tool to hyperpolarize small molecules in solution, however, has not …
resonance. A universal tool to hyperpolarize small molecules in solution, however, has not …
In vivo Metabolic Sensing of Hyperpolarized [1‐13C]Pyruvate in Mice Using a Recyclable Perfluorinated Iridium Signal Amplification by Reversible Exchange …
J Ettedgui, K Yamamoto, B Blackman… - Angewandte Chemie …, 2024 - Wiley Online Library
Real‐time visualization of metabolic processes in vivo provides crucial insights into
conditions like cancer and metabolic disorders. Metabolic magnetic resonance imaging …
conditions like cancer and metabolic disorders. Metabolic magnetic resonance imaging …
[HTML][HTML] Quo Vadis Hyperpolarized 13C MRI?
Over the last two decades, hyperpolarized 13 C MRI has gained significance in both
preclinical and clinical studies, hereby relying on technologies like PHIP-SAH …
preclinical and clinical studies, hereby relying on technologies like PHIP-SAH …
Delivering Robust Proton-Only Sensing of Hyperpolarized [1,2-13C2]-Pyruvate Using Broad-Spectral-Range Nuclear Magnetic Resonance Pulse Sequences
Hyperpolarized [1-13C] pyruvate is the leading hyperpolarized injectable contrast agent and
is currently under evaluation in clinical trials for molecular imaging of metabolic diseases …
is currently under evaluation in clinical trials for molecular imaging of metabolic diseases …
Spying on parahydrogen-induced polarization transfer using a half-tesla benchtop MRI and hyperpolarized imaging enabled by automation
Nuclear spin hyperpolarization is a quantum effect that enhances the nuclear magnetic
resonance signal by several orders of magnitude and has enabled real-time metabolic …
resonance signal by several orders of magnitude and has enabled real-time metabolic …
15N Hyperpolarization of Metronidazole Antibiotic in Aqueous Media Using Phase-Separated Signal Amplification by Reversible Exchange with Parahydrogen
SV Sviyazov, DB Burueva, NV Chukanov… - The Journal of …, 2024 - ACS Publications
Metronidazole is a prospective hyperpolarized MRI contrast agent with potential hypoxia
sensing utility for applications in cancer, stroke, neurodegenerative diseases, etc. We …
sensing utility for applications in cancer, stroke, neurodegenerative diseases, etc. We …