[HTML][HTML] Quo Vadis Hyperpolarized 13C MRI?
Over the last two decades, hyperpolarized 13 C MRI has gained significance in both
preclinical and clinical studies, hereby relying on technologies like PHIP-SAH …
preclinical and clinical studies, hereby relying on technologies like PHIP-SAH …
Over 20% carbon-13 polarization of perdeuterated pyruvate using reversible exchange with parahydrogen and spin-lock induced crossing at 50 μT
Carbon-13 hyperpolarized pyruvate is about to become the next-generation contrast agent
for molecular magnetic resonance imaging of cancer and other diseases. Here, efficient and …
for molecular magnetic resonance imaging of cancer and other diseases. Here, efficient and …
Spying on parahydrogen-induced polarization transfer using a half-tesla benchtop MRI and hyperpolarized imaging enabled by automation
Nuclear spin hyperpolarization is a quantum effect that enhances the nuclear magnetic
resonance signal by several orders of magnitude and has enabled real-time metabolic …
resonance signal by several orders of magnitude and has enabled real-time metabolic …
Perfluorinated Iridium Catalyst for Signal Amplification by Reversible Exchange Provides Metal-Free Aqueous Hyperpolarized [1-13C]-Pyruvate
J Ettedgui, B Blackman, N Raju, SA Kotler… - Journal of the …, 2023 - ACS Publications
Hyperpolarized (HP) carbon-13 [13C] enables the specific investigation of dynamic
metabolic and physiologic processes via in vivo MRI-based molecular imaging. As the …
metabolic and physiologic processes via in vivo MRI-based molecular imaging. As the …
Parahydrogen‐Polarized [1‐13C]Pyruvate for Reliable and Fast Preclinical Metabolic Magnetic Resonance Imaging
Hyperpolarization techniques increase nuclear spin polarization by more than four orders of
magnitude, enabling metabolic MRI. Even though hyperpolarization has shown clear value …
magnitude, enabling metabolic MRI. Even though hyperpolarization has shown clear value …
MATRESHCA: microtesla apparatus for transfer of resonance enhancement of spin hyperpolarization via chemical exchange and addition
We present an integrated, open-source device for parahydrogen-based hyperpolarization
processes in the microtesla field regime with a cost of components of less than $7000. The …
processes in the microtesla field regime with a cost of components of less than $7000. The …
J Coupling Constants of <1 Hz Enable 13C Hyperpolarization of Pyruvate via Reversible Exchange of Parahydrogen
Observing pyruvate metabolism in vivo has become a focal point of molecular magnetic
resonance imaging. Signal amplification by reversible exchange (SABRE) has recently …
resonance imaging. Signal amplification by reversible exchange (SABRE) has recently …
[HTML][HTML] Hyperpolarised benchtop NMR spectroscopy for analytical applications
Benchtop NMR spectrometers, with moderate magnetic field strengths (B 0= 1− 2. 4 T) and
sub-ppm chemical shift resolution, are an affordable and portable alternative to standard …
sub-ppm chemical shift resolution, are an affordable and portable alternative to standard …
Toward Next-Generation Molecular Imaging with a Clinical Low-Field (0.064 T) Point-of-Care MRI Scanner
N Iqbal, DO Brittin… - Analytical …, 2024 - ACS Publications
Low-field (LF) MRI promises soft-tissue imaging without the expensive, immobile magnets of
clinical scanners but generally suffers from limited detection sensitivity and contrast. The …
clinical scanners but generally suffers from limited detection sensitivity and contrast. The …
13C MRI of hyperpolarized pyruvate at 120 µT
Nuclear spin hyperpolarization increases the sensitivity of magnetic resonance dramatically,
enabling many new applications, including real-time metabolic imaging. Parahydrogen …
enabling many new applications, including real-time metabolic imaging. Parahydrogen …