Applications of focused ultrasound in the brain: from thermoablation to drug delivery
Focused ultrasound (FUS) is a disruptive medical technology, and its implementation in the
clinic represents the culmination of decades of research. Lying at the convergence of …
clinic represents the culmination of decades of research. Lying at the convergence of …
Non-invasive transcranial ultrasound stimulation for neuromodulation
Transcranial ultrasound stimulation (TUS) holds great potential as a tool to alter neural
circuits non-invasively in both animals and humans. In contrast to established non-invasive …
circuits non-invasively in both animals and humans. In contrast to established non-invasive …
[HTML][HTML] Ultrasound neuromodulation: a review of results, mechanisms and safety
Ultrasonic neuromodulation is a rapidly growing field, in which low-intensity ultrasound (US)
is delivered to nervous system tissue, resulting in transient modulation of neural activity. This …
is delivered to nervous system tissue, resulting in transient modulation of neural activity. This …
Ultrasound technologies for imaging and modulating neural activity
Visualizing and perturbing neural activity on a brain-wide scale in model animals and
humans is a major goal of neuroscience technology development. Established electrical and …
humans is a major goal of neuroscience technology development. Established electrical and …
Focused ultrasound excites cortical neurons via mechanosensitive calcium accumulation and ion channel amplification
Ultrasonic neuromodulation has the unique potential to provide non-invasive control of
neural activity in deep brain regions with high spatial precision and without chemical or …
neural activity in deep brain regions with high spatial precision and without chemical or …
Manipulation of subcortical and deep cortical activity in the primate brain using transcranial focused ultrasound stimulation
The causal role of an area within a neural network can be determined by interfering with its
activity and measuring the impact. Many current reversible manipulation techniques have …
activity and measuring the impact. Many current reversible manipulation techniques have …
The mechanosensitive ion channel Piezo1 contributes to ultrasound neuromodulation
J Zhu, Q **an, X Hou, KF Wong, T Zhu… - Proceedings of the …, 2023 - National Acad Sciences
Transcranial low-intensity ultrasound is a promising neuromodulation modality, with the
advantages of noninvasiveness, deep penetration, and high spatiotemporal accuracy …
advantages of noninvasiveness, deep penetration, and high spatiotemporal accuracy …
Low-intensity ultrasound neuromodulation: an overview of mechanisms and emerging human applications
Background There is an emerging need for noninvasive neuromodulation techniques to
improve patient outcomes while minimizing adverse events and morbidity. Low-intensity …
improve patient outcomes while minimizing adverse events and morbidity. Low-intensity …
Ultrasound as a versatile tool for short-and long-term improvement and monitoring of brain function
Treating the brain with focused ultrasound (FUS) at low intensities elicits diverse responses
in neurons, astroglia, and the extracellular matrix. In combination with intravenously injected …
in neurons, astroglia, and the extracellular matrix. In combination with intravenously injected …
Ultrasound produces extensive brain activation via a cochlear pathway
Ultrasound (US) can noninvasively activate intact brain circuits, making it a promising
neuromodulation technique. However, little is known about the underlying mechanism …
neuromodulation technique. However, little is known about the underlying mechanism …