Mounting evidence has firmly established that low levels of cardiorespiratory fitness (CRF)
are associated with a high risk of cardiovascular disease, all-cause mortality, and mortality …

Adult neurogenesis, a process of generating functional neurons from adult neural
precursors, occurs throughout life in restricted brain regions in mammals. The past decade …

Disrupted hippocampal performance underlies psychiatric comorbidities and cognitive
impairments in patients with neurodegenerative disorders. To understand the contribution of …

There is a growing body of evidence demonstrating that stress decreases the expression of
brain-derived neurotrophic factor (BDNF) in limbic structures that control mood and that …

The blood-brain barrier (BBB) is a highly specialized brain endothelial structure of the fully
differentiated neurovascular system. In concert with pericytes, astrocytes, and microglia, the …

To improve our ability to identify hematopoietic stem cells (HSCs) and their localization in
vivo, we compared the gene expression profiles of highly purified HSCs and non-self …

The generation of new neurons is sustained throughout adulthood in the mammalian brain
due to the proliferation and differentiation of adult neural stem cells. In this review, we …

Of the neurogenic zones in the adult brain, adult hippocampal neurogenesis attracts the
most attention, because it is involved in higher cognitive function, most notably memory …

The blood–brain barrier (BBB) is a diffusion barrier, which impedes influx of most
compounds from blood to brain. Three cellular elements of the brain microvasculature …

Glial cells were long considered end products of neural differentiation, specialized
supportive cells with an origin very different from that of neurons. New studies have shown …