Despite its history as a human teratogen, thalidomide is emerging as a treatment for cancer
and inflammatory diseases. Although the evolution of its clinical application could not have …

Crohn's disease (CD) and ulcerative colitis (UC) are chronic inflammatory diseases of the
gastrointestinal tract. While a cure remains elusive, both can be treated with medications that …

Although thalidomide (Thal) does not directly induce T-cell activation, it increases
proliferation of T cells following CD3 activation. In this study, we examined the …

Standard of care for ulcerative colitis involves long‐term pharmacotherapy or colectomy.
Approximately 20% to 30% of patients eventually require a colectomy because patients …

Background Histologic assessment of mucosal disease activity has been increasingly used
in clinical trials of treatment for Crohn's disease. However, the operating properties of the …

Background Ulcerative colitis (UC) is an idiopathic inflammatory disorder. Currently, the
main goals of treatment are to induce and maintain clinical and/or endoscopic remission …

Importance Pediatric-onset Crohn disease is more aggressive than adult-onset disease, has
high rates of resistance to existing drugs, and can lead to permanent impairments. Few trials …

Behçet's disease (BD) is a multi-systemic inflammatory disorder of an unknown etiology and
shows a chronic recurrent clinical course. When the disease involves the alimentary tract, it …

Inflammatory bowel diseases (IBDs) are chronic inflammatory disorders of the intestinal tract
with unknown multifactorial etiology that, among other things, result in alteration and …

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