The bacterial two-hybrid system based on the reconstitution of adenylate cyclase in
Escherichia coli (BACTH) was described 14years ago (Karimova, Pidoux, Ullmann, and …

Highlights•The discovery of the FtsZ ring by Bi and Lutkenhaus in 1991 was a defining
moment in the field of bacterial cell division.•The past 25 years of research have significantly …

Limits and barriers to adaptation restrict people's ability to address the negative impacts of
climate change or manage risks in a way that maximises their wellbeing. There is a lack of …

The growing problem of antibiotic resistance has been exacerbated by the use of new drugs
that are merely variants of older overused antibiotics. While it is naive to expect to restrain …

From microbes to multicellular eukaryotic organisms, all cells contain pathways responsible
for genome maintenance. DNA replication allows for the faithful duplication of the genome …

The characteristic shape of bacterial cells is mainly determined by the cell wall, the synthesis
of which is orchestrated by penicillin‐binding proteins (PBPs). Rod‐shaped bacteria have …

Cell division in bacteria is carried out by about a dozen proteins which assemble at midcell
and form a complex known as the divisome. To study the dynamics and temporal hierarchy …

S treptococcus pneumoniae is an oval‐shaped G ram‐positive coccus that lives in intimate
association with its human host, both as a commensal and pathogen. The seriousness of …

Bacillus subtilis is the best described member of the Gram positive bacteria. It is a typical rod
shaped bacterium and grows by elongation in its long axis, before dividing at mid cell to …

Cytokinesis in Gram‐negative bacteria is mediated by a multiprotein machine (the divisome)
that invaginates and remodels the inner membrane, peptidoglycan and outer membrane …