Primary familial brain calcification (PFBC) is characterized by calcium deposition in the
brain, causing progressive movement disorders, psychiatric symptoms, and cognitive …

Actin is a critical component of the eukaryotic cytoskeleton. In animals, actins undergo
unique N-terminal processing by dedicated enzymes resulting in mature acidic and …

The ribosome-tethered N-terminal acetyltransferase A (NatA) acetylates 52% of soluble
proteins in Arabidopsis thaliana. This co-translational modification of the N terminus …

Acetyltransferases, required to transfer an acetyl group on protein are highly conserved
proteins that play a crucial role in development and disease. Protein acetylation is a …

The DNA damage response (DDR) constitutes a vital cellular process that safeguards
genome integrity. This biological process involves substantial alterations in chromatin …

N-terminal acetylation is being recognized as a factor affecting protein lifetime and
proteostasis. It is a modification where an acetyl group is added to the N-terminus of …

Axonemal dyneins are highly complex microtubule motors that power ciliary motility. These
multi-subunit enzymes are assembled at dedicated sites within the cytoplasm. At least …

Cell death can occur through programmed self-destruction, internal sabotage, accidental
damage, or immune cell-mediated killing (Green, 2024). Among these, ferroptosis is a …

The high-throughput proteomics data generated by increasingly more sensible mass
spectrometers greatly contribute to our better understanding of molecular and cellular …

N-alpha-acetyltransferase 40 (NAA40) is an evolutionarily conserved N-terminal
acetyltransferase (NAT) linked to oncogenesis and chemoresistance. A recent study …