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Deciphering cell–cell interactions and communication from gene expression
Cell–cell interactions orchestrate organismal development, homeostasis and single-cell
functions. When cells do not properly interact or improperly decode molecular messages …
functions. When cells do not properly interact or improperly decode molecular messages …
Single-cell transcriptomics for the assessment of cardiac disease
AMA Miranda, V Janbandhu, H Maatz… - Nature Reviews …, 2023 - nature.com
Cardiovascular disease is the leading cause of death globally. An advanced understanding
of cardiovascular disease mechanisms is required to improve therapeutic strategies and …
of cardiovascular disease mechanisms is required to improve therapeutic strategies and …
[HTML][HTML] Cannabinoid receptor 1 antagonist genistein attenuates marijuana-induced vascular inflammation
Epidemiological studies reveal that marijuana increases the risk of cardiovascular disease
(CVD); however, little is known about the mechanism. Δ 9-tetrahydrocannabinol (Δ 9-THC) …
(CVD); however, little is known about the mechanism. Δ 9-tetrahydrocannabinol (Δ 9-THC) …
Addressing variability in iPSC-derived models of human disease: guidelines to promote reproducibility
Induced pluripotent stem cell (iPSC) technologies have provided in vitro models of
inaccessible human cell types, yielding new insights into disease mechanisms especially for …
inaccessible human cell types, yielding new insights into disease mechanisms especially for …
Multi-lineage human iPSC-derived platforms for disease modeling and drug discovery
Human induced pluripotent stem cells (hiPSCs) provide a powerful platform for disease
modeling and have unlocked new possibilities for understanding the mechanisms governing …
modeling and have unlocked new possibilities for understanding the mechanisms governing …
Single-cell RNA sequencing in cardiovascular development, disease and medicine
Advances in single-cell RNA sequencing (scRNA-seq) technologies in the past 10 years
have had a transformative effect on biomedical research, enabling the profiling and analysis …
have had a transformative effect on biomedical research, enabling the profiling and analysis …
Single-cell RNA sequencing unveils unique transcriptomic signatures of organ-specific endothelial cells
Background: Endothelial cells (ECs) display considerable functional heterogeneity
depending on the vessel and tissue in which they are located. Whereas these functional …
depending on the vessel and tissue in which they are located. Whereas these functional …
Single-cell reconstruction of progression trajectory reveals intervention principles in pathological cardiac hypertrophy
Z Ren, P Yu, D Li, Z Li, Y Liao, Y Wang, B Zhou… - Circulation, 2020 - ahajournals.org
Background: Pressure overload–induced pathological cardiac hypertrophy is a common
predecessor of heart failure, the latter of which remains a major cardiovascular disease with …
predecessor of heart failure, the latter of which remains a major cardiovascular disease with …
[HTML][HTML] Integrative single-cell analysis of cardiogenesis identifies developmental trajectories and non-coding mutations in congenital heart disease
To define the multi-cellular epigenomic and transcriptional landscape of cardiac cellular
development, we generated single-cell chromatin accessibility maps of human fetal heart …
development, we generated single-cell chromatin accessibility maps of human fetal heart …