Natural products for drug discovery in the 21st century: innovations for novel drug discovery
The therapeutic properties of plants have been recognised since time immemorial. Many
pathological conditions have been treated using plant-derived medicines. These medicines …
pathological conditions have been treated using plant-derived medicines. These medicines …
[HTML][HTML] The role of natural products as sources of therapeutic agents for innovative drug discovery
K Dzobo - Comprehensive pharmacology, 2022 - ncbi.nlm.nih.gov
Emerging threats to human health require a concerted effort in search of both preventive and
treatment strategies, placing natural products at the center of efforts to obtain new therapies …
treatment strategies, placing natural products at the center of efforts to obtain new therapies …
Single-cell RNA sequencing reveals the tumor microenvironment and facilitates strategic choices to circumvent treatment failure in a chemorefractory bladder cancer …
HW Lee, W Chung, HO Lee, DE Jeong, A Jo, JE Lim… - Genome medicine, 2020 - Springer
Background Tumor cell-intrinsic mechanisms and complex interactions with the tumor
microenvironment contribute to therapeutic failure via tumor evolution. It may be possible to …
microenvironment contribute to therapeutic failure via tumor evolution. It may be possible to …
Chemoresistance and the self-maintaining tumor microenvironment
The progression of cancer is associated with alterations in the tumor microenvironment,
including changes in extracellular matrix (ECM) composition, matrix rigidity …
including changes in extracellular matrix (ECM) composition, matrix rigidity …
Deciphering tumour heterogeneity: from tissue to liquid biopsy
Simple Summary Most malignant tumours are highly heterogeneous at molecular and
phenotypic levels. Tumour variability poses challenges for the management of patients, as it …
phenotypic levels. Tumour variability poses challenges for the management of patients, as it …
[HTML][HTML] The relationship between innovative human capital and interprovincial economic growth based on panel data model and spatial econometrics
Y Xu, A Li - Journal of computational and applied mathematics, 2020 - Elsevier
At present, with the rapid development of knowledge economy and network, innovative
human capital is an important factor in a region. At present, there are some features of the …
human capital is an important factor in a region. At present, there are some features of the …
Integrating artificial and human intelligence: a partnership for responsible innovation in biomedical engineering and medicine
Historically, the term “artificial intelligence” dates to 1956 when it was first used in a
conference at Dartmouth College in the US. Since then, the development of artificial …
conference at Dartmouth College in the US. Since then, the development of artificial …
Fibroblasts as turned agents in cancer progression
R Wieder - Cancers, 2023 - mdpi.com
Simple Summary Normal epithelial cells in our organs are surrounded by stroma, which is
an ecosystem made up of a variety of cells and proteins that support their intended functions …
an ecosystem made up of a variety of cells and proteins that support their intended functions …
Unveiling the mechanisms and challenges of cancer drug resistance
Cancer treatment faces many hurdles and resistance is one among them. Anti-cancer
treatment strategies are evolving due to innate and acquired resistance capacity, governed …
treatment strategies are evolving due to innate and acquired resistance capacity, governed …
Super-enhancers: a new frontier for epigenetic modifiers in cancer chemoresistance
GH Li, Q Qu, TT Qi, XQ Teng, HH Zhu, JJ Wang… - Journal of Experimental …, 2021 - Springer
Although new developments of surgery, chemotherapy, radiotherapy, and immunotherapy
treatments for cancer have improved patient survival, the emergence of chemoresistance in …
treatments for cancer have improved patient survival, the emergence of chemoresistance in …