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Cellular and pathological functions of tau
Tau protein is involved in various cellular processes, including having a canonical role in
binding and stabilization of microtubules in neurons. Tauopathies are neurodegenerative …
binding and stabilization of microtubules in neurons. Tauopathies are neurodegenerative …
Multifaceted roles of APOE in Alzheimer disease
For the past three decades, apolipoprotein E (APOE) has been known as the single greatest
genetic modulator of sporadic Alzheimer disease (AD) risk, influencing both the average age …
genetic modulator of sporadic Alzheimer disease (AD) risk, influencing both the average age …
Antibody-mediated targeting of human microglial leukocyte Ig-like receptor B4 attenuates amyloid pathology in a mouse model
Microglia help limit the progression of Alzheimer's disease (AD) by constraining amyloid-β
(Aβ) pathology, effected through a balance of activating and inhibitory intracellular signals …
(Aβ) pathology, effected through a balance of activating and inhibitory intracellular signals …
Innate immune activation in neurodegenerative diseases
Activation of the innate immune system following pattern recognition receptor binding has
emerged as one of the major pathogenic mechanisms in neurodegenerative disease …
emerged as one of the major pathogenic mechanisms in neurodegenerative disease …
Updates in Alzheimer's disease: from basic research to diagnosis and therapies
E Liu, Y Zhang, JZ Wang - Translational Neurodegeneration, 2024 - Springer
Alzheimer's disease (AD) is the most common neurodegenerative disorder, characterized
pathologically by extracellular deposition of β-amyloid (Aβ) into senile plaques and …
pathologically by extracellular deposition of β-amyloid (Aβ) into senile plaques and …
Single-nucleus RNA sequencing demonstrates an autosomal dominant Alzheimer's disease profile and possible mechanisms of disease protection
Highly penetrant autosomal dominant Alzheimer's disease (ADAD) comprises a distinct
disease entity as compared to the far more prevalent form of AD in which common variants …
disease entity as compared to the far more prevalent form of AD in which common variants …
[HTML][HTML] New insights into innate immunity in Alzheimer's disease: From APOE protective variants to therapies
Recent discoveries of rare variants of human APOE may shed light on novel therapeutic
strategies for Alzheimer's disease (AD). Here, we highlight the newly identified protective …
strategies for Alzheimer's disease (AD). Here, we highlight the newly identified protective …
APOE from astrocytes restores Alzheimer's Aβ-pathology and DAM-like responses in APOE deficient microglia
P Preman, D Moechars, E Fertan, L Wolfs… - EMBO Molecular …, 2024 - embopress.org
The major genetic risk factor for Alzheimer's disease (AD), APOE4, accelerates beta-amyloid
(Aβ) plaque formation, but whether this is caused by APOE expressed in microglia or …
(Aβ) plaque formation, but whether this is caused by APOE expressed in microglia or …
Report of the APOE4 National Institute on Aging/Alzheimer disease sequencing project consortium working group: reducing APOE4 in carriers is a therapeutic goal for …
Alzheimer's disease (AD) is the most common neurodegenerative disorder and one of the
leading causes of disability worldwide. The apolipoprotein E4 gene (APOE4) is the strongest …
leading causes of disability worldwide. The apolipoprotein E4 gene (APOE4) is the strongest …
An enzymatically activated AND-gate DNA logic circuit for tumor cells recognition via multi-microRNAs detection
H Yan, G Cao, J Wang, X Zhu, S Dong, Y Huang… - Biosensors and …, 2024 - Elsevier
The DNA-based logic circuit, constructed to mimic biochemical reaction networks, is highly
significant in detecting biomarkers at the molecular level. The differences in the expression …
significant in detecting biomarkers at the molecular level. The differences in the expression …