Herein, the privilege in favor of biological importance of indole-containing scaffolds related
to the semi-synthetic and extracted from natural sources is summarized. Such compounds …

In this review, we describe a collection and assessment of 16 anticancer drugs approved by
the US FDA between 2021 to June 2022, which include small and big amide group …

A highly stereo-selective, one-pot, multicomponent method was chosen to synthesize the
novel functionalized 1, 3-cycloaddition spirooxindoles (SOXs)(4a–4h). Synthesized SOXs …

Herein, the one-step, multi-component reaction (MCR) of a series of spirooxindole-
pyranopyrazole derivatives (5a-g), via a Knoevenagel condensation and Michael addition …

Herein, we present a one‐pot, three‐component synthesis of spirooxindole‐oxofuran
carboxylate derivatives (4 a–d) through the Huisgen reaction. The newly synthesized …

The pyrazoline scaffold plays a vital role in heterocyclic chemistry as a fundamental building
block in both organic and medicinal chemistry. A pyrazoline scaffold is composed of an …

Herein, click chemistry was chosen to synthesize 2AIPC using Knoevenegel and Michael
addition reactions. In this synthesis, Lewis base was attracted by the generation of sp 3 …

Herein, the one-keto protected and one-keto transformed into the imine-functionalized Schiff
bases (7a–b) through the 1, 2-dimethoxy-1, 2-dihydroacenaphthylene using calcium oxo …

In the present study, a series of isatin bis-imidathiazole hybrids was designed and
synthesized to develop a new class of heterocyclic compounds with improved antimicrobial …

The design of novel antimicrobial drugs is necessary due to the increasing resistance to
many existing antibiotics. Considering that the drug discovery process requires a lot of time …