Transition metals, which are of diversity in their bonding orbitals, have a variety of significant
oxidation states and more complex chemical properties compared to the main group metals …

In this review the current state‐of‐the‐art of S‐adenosylmethionine (SAM)‐dependent
methyltransferases and SAM are evaluated. Their structural classification and diversity is …

Enzyme catalysis is gaining increasing importance in synthetic chemistry. Nowadays, the
growing number of biocatalysts accessible by means of bioinformatics and enzyme …

The generation of enantiodivergent biocatalysts for C–H oxyfunctionalizations is ever more
important in modern synthetic chemistry. Here, we have applied the FuncLib algorithm …

Chiral N-cyclopropyl pyrazoles and structurally related heterocycles are prepared using an
earth-abundant copper catalyst under mild reaction conditions with high regio-, diastereo …

Mutations in protein active sites can dramatically improve function. The active site, however,
is densely packed and extremely sensitive to mutations. Therefore, some mutations may …

Late‐stage methylation is a key technology in the development of pharmaceutical
compounds. Methyltransferase biocatalysis may provide powerful options to insert methyl …

Methods for regioselective N‐methylation and‐alkylation of unsaturated heterocycles with
“off the shelf” reagents are highly sought‐after. This reaction could drastically simplify …

Catalytic asymmetric α-alkylation of carbonyl compounds represents a long-standing
challenge in synthetic organic chemistry. Herein, we advance a dual biocatalytic platform for …

Mutations in a protein active site can lead to dramatic and useful changes in protein activity.
The active site, however, is sensitive to mutations due to a high density of molecular …