The nematode Caenorhabditis elegans has been a model for studying infection since the
early 2000s and many major discoveries have been made regarding its innate immune …

In its natural habitat, C. elegans encounters a wide variety of microbes, including food,
commensals and pathogens. To be able to survive long enough to reproduce, C. elegans …

Upon sensing viral RNA, mammalian RIG-I-like receptors (RLRs) activate downstream
signals using caspase activation and recruitment domains (CARDs), which ultimately …

Miniaturization of sample preparation, including omissible manual sample handling steps, is
key for reproducible nanoproteomics, as material is often restricted to only hundreds of cells …

Intestinal epithelial cells are subject to attack by a diverse array of microbes, including
intracellular as well as extracellular pathogens. While defense in epithelial cells can be …

Defense against intracellular infection has been extensively studied in vertebrate hosts, but
less is known about invertebrate hosts; specifically, the transcription factors that induce …

Most of the sequenced wood-rotting edible mushroom produce fruiting body at relatively low
temperatures. Little information has been known about the high-temperature wood-rotting …

Intracellular pathogens are challenged with limited space and resources while replicating in
a single host cell. Mechanisms for direct invasion of neighboring host cells have been …

Microsporidia are poorly understood, ubiquitous eukaryotic parasites that are completely
dependent on their hosts for replication. With the discovery of microsporidia species …

The transcription factor HSF‐1 (heat shock factor 1) acts as a master regulator of heat shock
response in eukaryotic cells to maintain cellular proteostasis. The protein has a protective …