Microtubules are core components of the eukaryotic cytoskeleton with essential roles in cell
division, sha**, motility and intracellular transport. Despite their functional heterogeneity …

N ε-lysine acetylation was discovered more than half a century ago as a post-translational
modification of histones and has been extensively studied in the context of transcription …

Post-translational modifications, such as phosphorylation, ubiquitination and acetylation,
play crucial roles in the regulation of autophagy. Acetylation has emerged as an important …

Autophagy is a conserved lysosomal degradation pathway where cellular components are
dynamically degraded and re-processed to maintain physical homeostasis. However, the …

In selective autophagy, cytoplasmic components are selected and tagged before being
sequestered into an autophagosome by means of selective autophagy receptors such as …

Over the last several decades, it has become clear that epigenetic abnormalities may be one
of the hallmarks of cancer. Posttranslational modifications of histones, for example, may play …

The ubiquitin–proteasome system (UPS) and autophagy are two distinct and interacting
proteolytic systems. They play critical roles in cell survival under normal conditions and …

Macroautophagy (autophagy) is a conserved lysosomal degradation process essential for
cellular homeostasis and adaption to stress. Accumulating evidence indicates that …

Autophagy and the ubiquitin–proteasome system are the two major quality control pathways
responsible for cellular homeostasis. As such, they provide protection against age …

Macroautophagy is a conserved catabolic process observed in all eukaryotic cells, during
which selected cellular components are transported to and broken down within lysosomes …