Adenosine deaminase acting on RNA (ADAR) catalyzes the posttranscriptional conversion
of adenosine to inosine in double‐stranded RNA (dsRNA), which can lead to the creation of …

Specialized receptors that recognize molecular patterns such as double stranded RNA
duplexes—indicative of viral replication—are potent triggers of the innate immune system …

Cell death provides host defense and maintains homeostasis. Zα-containing molecules are
essential for these processes. Z-DNA binding protein 1 (ZBP1) activates inflammatory cell …

Effective immunity requires the innate immune system to distinguish foreign nucleic acids
from cellular ones. Cellular double-stranded RNAs (dsRNAs) are edited by the RNA-editing …

Systematic exploration of cancer cell vulnerabilities can inform the development of novel
cancer therapeutics. Here, through analysis of genome-scale loss-of-function datasets, we …

Cell death resistance is a key feature of tumor cells. One of the main anticancer therapies is
increasing the susceptibility of cells to death. Cancer cells have developed a capability of …

A-to-I RNA editing, the deamination of adenosine (A) to inosine (I) that occurs in regions of
RNA with double-stranded character, is catalyzed by a family of Adenosine Deaminases …

There is considerable HIV-1 variation in patients. The extent of the variation is due to the
high rate of viral replication, the high viral load, and the errors made during viral replication …

Proteasome dysfunction can lead to autoinflammatory disease associated with elevated type
I interferon (IFN-αβ) and NF-κB signaling; however, the innate immune pathway driving this …

C6 deamination of adenosine (A) to inosine (I) in double-stranded RNA (dsRNA) is
catalyzed by a family of enzymes known as ADARs (adenosine deaminases acting on RNA) …