Tyrosine kinases, enzymes that catalyze the transfer of phosphate from ATP to tyrosine
residues in polypeptides, are ubiquitous, numerous, and of considerable clinical interest …

The calcium binding protein S100 family in humans contains 21 known members, with each
possessing a molecular weight between 10 and 14 kDa. These proteins are characterized …

Thyroid cancer poses a significant clinical challenge, and our understanding of its
pathogenesis is incomplete. To gain insight into the pathogenesis of papillary thyroid …

Sarcomas are a biologically complex group of tumors of mesenchymal origin. By using gene
expression microarray analysis, we aimed to find clues into the cellular differentiation and …

Oncogenic fusion proteins generated by chromosomal translocations play major roles in
cancer. Among them, fusions between EWSR1 and transcription factors generate …

cAMP responsive element-binding protein (CREB) is one of the most intensively studied
phosphorylation-dependent transcription factors that provide evolutionarily conserved …

ERBB3, a member of the epidermal growth factor receptor (EGFR) family, is unique in that its
tyrosine kinase domain is functionally defective. It is activated by neuregulins, by other …

The human epidermal growth family (HER) of tyrosine kinase receptors underlies the
pathogenesis of many types of human cancer. The oncogenic functions of three of the HER …

Protein kinases constitute a large family of regulatory enzymes involved in the homeostasis
of virtually every cellular process. Subversion of protein kinases has been frequently …

Clear cell sarcoma (CCS) harbors a pathognomonic chromosomal translocation fusing the
Ewing's sarcoma gene (EWS) to the CREB family transcription factor ATF1 and exhibits …