Ultrasmall nanoparticles are often grouped under the broad umbrella term of “nanoparticles”
when reported in the literature. However, for biomedical applications, their small sizes give …

The idea that tumour microenvironment (TME) is organised in a spatial manner will not
surprise many cancer biologists; however, systematically capturing spatial architecture of …

The state and behaviour of a cell can be influenced by both genetic and environmental
factors. In particular, tumour progression is determined by underlying genetic aberrations …

Necrosis in the tumor interior is a common feature of aggressive cancers that is associated
with poor clinical prognosis and the development of metastasis. How the necrotic core …

In this opinion, we highlight agent-based modeling as a key tool for exploration of cell–cell
and cell–environment interactions that drive cancer progression, therapeutic resistance, and …

Spatial properties of tumour growth have profound implications for cancer progression,
therapeutic resistance and metastasis. Yet, how spatial position governs tumour cell division …

Genetic intra-tumour heterogeneity fuels clonal evolution, but our understanding of clinically
relevant clonal dynamics remain limited. We investigated spatial and temporal features of …

Since central cells are more malignant and aggressive in solid tumors, improving
penetration of therapeutic agents and activating immunity in tumor centers exhibit great …

Solid tumors are complex ecosystems with heterogeneous 3D structures, but the spatial intra-
tumor heterogeneity (sITH) at the macroscopic (ie, whole tumor) level is under-explored …

Renal medullary carcinoma (RMC) is an aggressive kidney cancer that almost exclusively
develops in individuals with sickle cell trait (SCT) and is always characterized by loss of the …