Small-angle scattering (SAS) is a technique that is able to probe the structural organization
of matter and quantify its response to changes in external conditions. X-ray and neutron …

Mammalian skeletal muscle shows an enormous variability in its functional features such as
rate of force production, resistance to fatigue, and energy metabolism, with a wide spectrum …

In a wide variety of cellular settings, from organelle transport to muscle contraction, Ca2+
binding to members of the EF hand family of proteins controls the interaction between actin …

We present a current perception of the regulation of activation of cardiac myofilaments with
emphasis on troponin (Tn) and tropomyosin (Tm). Activation involves both a Ca2+-regulated …

Troponin senses Ca2+ to regulate contraction in striated muscle. Structures of skeletal
muscle troponin composed of TnC (the sensor), TnI (the regulator), and TnT (the link to the …

This review discusses the structure and properties of the isolated components of troponin,
their interaction, and the mechanisms of regulation of contractile activity of skeletal and …

Introduction 3. Subunit structure-function, subunit-subunit interactions, isoforms, and tissue
distribution 3.1. Subunit structure-function, subunit-subunit interactions 3.1. 1. The gamma …

Small-angle neutron scattering with contrast variation can fill important gaps in our
understanding of biomolecular assemblies, providing constraints that can aid in the …

TN-I occurs as a homologous group of proteins which form part of the regulatory system of
vertebrate and invertebrate striated muscle. These proteins are present in vertebrate muscle …

Cardiac failure is one of the leading causes of mortality in developed countries. As life
expectancies of the populations of these countries grow, the number of patients suffering …