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High-throughput fluorescence microscopy for systems biology
In this post-genomic era, we need to define gene function on a genome-wide scale for
model organisms and humans. The fundamental unit of biological processes is the cell …
model organisms and humans. The fundamental unit of biological processes is the cell …
Increasing the content of high-content screening: an overview
Target-based high-throughput screening (HTS) has recently been critiqued for its relatively
poor yield compared to phenotypic screening approaches. One type of phenotypic …
poor yield compared to phenotypic screening approaches. One type of phenotypic …
[HTML][HTML] A human protein atlas for normal and cancer tissues based on antibody proteomics
Antibody-based proteomics provides a powerful approach for the functional study of the
human proteome involving the systematic generation of protein-specific affinity reagents. We …
human proteome involving the systematic generation of protein-specific affinity reagents. We …
Immunofluorescence and fluorescent-protein tagging show high correlation for protein localization in mammalian cells
Imaging techniques such as immunofluorescence (IF) and the expression of fluorescent
protein (FP) fusions are widely used to investigate the subcellular distribution of proteins …
protein (FP) fusions are widely used to investigate the subcellular distribution of proteins …
[HTML][HTML] Automated subcellular location determination and high-throughput microscopy
Dramatic advances in methods for protein tagging and the development of fully automated
microscopes enable collection of unprecedented volumes of image data on the subcellular …
microscopes enable collection of unprecedented volumes of image data on the subcellular …
Reverse transfection on cell arrays for high content screening microscopy
Here, we describe a robust protocol for the reverse transfection of cells on small interfering
(siRNA) arrays, which, in combination with multi-channel immunofluorescence or time-lapse …
(siRNA) arrays, which, in combination with multi-channel immunofluorescence or time-lapse …
Subcellular fractionation methods and strategies for proteomics
Developments in subcellular fractionation strategies have provided the means to profile and
analyze the protein composition of organelles and cellular structures by proteomics. Here …
analyze the protein composition of organelles and cellular structures by proteomics. Here …
VMP1 establishes ER-microdomains that regulate membrane contact sites and autophagy
The endoplasmic reticulum (ER) regulates organelle dynamics through the formation of
membrane contact sites (MCS). Here we describe that VMP1, a multispanning ER-resident …
membrane contact sites (MCS). Here we describe that VMP1, a multispanning ER-resident …
The potential of high‐content high‐throughput microscopy in drug discovery
Fluorescence microscopy is a powerful method to study protein function in its natural habitat,
the living cell. With the availability of the green fluorescent protein and its spectral variants …
the living cell. With the availability of the green fluorescent protein and its spectral variants …
miR-378a-3p modulates tamoxifen sensitivity in breast cancer MCF-7 cells through targeting GOLT1A
K Ikeda, K Horie-Inoue, T Ueno, T Suzuki, W Sato… - Scientific reports, 2015 - nature.com
Breast cancer is a hormone-dependent cancer and usually treated with endocrine therapy
using aromatase inhibitors or anti-estrogens such as tamoxifen. A majority of breast cancer …
using aromatase inhibitors or anti-estrogens such as tamoxifen. A majority of breast cancer …