Hypertension (HTN) is one of the most prevalent diseases worldwide and is among the most
important risk factors for cardiovascular and cerebrovascular complications. It is currently …

The endothelins comprise three structurally similar 21-amino acid peptides. Endothelin-1
and-2 activate two G-protein coupled receptors, ET A and ET B, with equal affinity, whereas …

The principal cell of the kidney collecting duct is one of the most highly regulated epithelial
cell types in vertebrates. The effects of hormonal, autocrine, and paracrine factors to regulate …

Despite major advances in understanding the pathophysiology of hypertension and
availability of effective and safe antihypertensive drugs, suboptimal blood pressure (BP) …

Background Evidence of the clinical safety of endothelin receptor antagonists (ERAs) is
limited and derived mainly from individual trials; therefore, we conducted a meta‐analysis …

Hall Kidney Dysfunction in Salt-Induced Hypertension 895 induced experimentally or by
genetic mutations, has not been shown to increase salt sensitivity of BP. In this review, I …

Objectives: The objective of this clinical trial was to evaluate the long-term effect of
endothelin receptor antagonism with bosentan on the morbidity and mortality of patients with …

Substantial follicle remodelling during the regression phase of the hair growth cycle is
coordinated by the contraction of the dermal sheath smooth muscle, but how dermal-sheath …

Endothelin-1 (ET-1) is a multifunctional hormone which regulates the physiology of the
cardiovascular and renal systems. ET-1 modulates cardiac contractility, systemic and renal …

Based on the reports reviewed in here, targeting of the renal endothelin system is a possible
therapeutic approach against the development of glomerular injury. More animal and clinical …