Mycobacterium tuberculosis (M. tb), the causative agent of TB, is a recalcitrant pathogen that
is rife around the world, latently infecting approximately a quarter of the worldwide …

Over the past 2000 years, tuberculosis (TB) has claimed more lives than any other infectious
disease. In 2020 alone, TB was responsible for 1.5 million deaths worldwide, comparable to …

The development of new and effective antibacterial drugs to treat multi-drug resistant (MDR)
bacteria, especially Gram-negative (G− ve) pathogens, is acknowledged as one of the …

Inadequate dosing and incomplete treatment regimens, coupled with the ability of the
tuberculosis bacilli to cause latent infections that are tolerant of currently used drugs, have …

Tuberculosis (TB) is a serious public health problem worldwide. Its situation is worsened by
the presence of multidrug resistant (MDR) strains of Mycobacterium tuberculosis, the …

While broad spectrum antibiotics play an invaluable role in the treatment of bacterial
infections, there are some drawbacks to their use, namely selection for and spread of …

The causative agent of tuberculosis (TB), Mycobacterium tuberculosis and more recently
totally drug‐resistant strains of M. tuberculosis, display unique mechanisms to survive in the …

The antileprosy drug clofazimine is also of interest for the treatment of multidrug-resistant
tuberculosis. To understand possible resistance mechanisms, clofazimine-resistant …

Small molecules with antitubercular activity containing the pyrimidine motif in their structure
have gained more attention after three drugs, namely GSK 2556286 (GSK-286), TBA-7371 …

Mycobacterium tuberculosis (Mtb), the etiological agent of tuberculosis (TB), is recognized
as a global health emergency as promoted by the World Health Organization. Over 1 million …