Protein phosphatases act as key regulators of multiple important cellular processes and are
attractive therapeutic targets for various diseases. Although extensive effort has been …

The incidence of autoimmune diseases is increasing worldwide, thus stimulating studies on
their etiopathogenesis, derived from a complex interaction between genetic and …

For more than 35 years, the NOD mouse has been the primary animal model for studying
autoimmune diabetes. During this time, striking similarities to the human disease have been …

It is known that the etiology and clinical outcomes of autoimmune diseases are associated
with a combination of genetic and environmental factors. In the case of the genetic factor, the …

The Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR) mediated Cas9
nuclease system has been extensively used for genome editing and gene modification in …

Type 1 diabetes (T1D) is a chronic autoimmune disease characterized by the destruction of
insulin-producing pancreatic β-cells by the immune system. Although conventional …

Autoimmune diseases such as systemic lupus erythematosus (SLE) display a strong female
bias. Although sex hormones have been associated with protecting males from …

Summary Type 1 diabetes (T1D) results from a complex interplay of genetic predisposition,
immunological dysregulation, and environmental triggers, that culminate in the destruction of …

Diabetes is a chronic disorder with rapidly increasing prevalence that is a major global issue
of our current era. There are two major types of diabetes. Polygenic forms of diabetes …

Modeling human disease has proven to be a challenge for the scientific community. For
years, generating an animal model was complicated and restricted to very few species. With …